node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GPR37 | NPB | ENSP00000306449 | ENSP00000332766 | Prosaposin receptor GPR37; Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade; Belongs to the G-protein coupled receptor 1 family. | Neuropeptide B-23; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. | 0.523 |
GPR37 | NPBWR1 | ENSP00000306449 | ENSP00000330284 | Prosaposin receptor GPR37; Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade; Belongs to the G-protein coupled receptor 1 family. | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B. | 0.526 |
GPR37 | NPBWR2 | ENSP00000306449 | ENSP00000358783 | Prosaposin receptor GPR37; Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade; Belongs to the G-protein coupled receptor 1 family. | Neuropeptides B/W receptor type 2; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals; Belongs to the G-protein coupled receptor 1 family. | 0.593 |
GPR37 | NPW | ENSP00000306449 | ENSP00000456974 | Prosaposin receptor GPR37; Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade; Belongs to the G-protein coupled receptor 1 family. | Neuropeptide W-23; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30. | 0.507 |
GPR37 | NPY | ENSP00000306449 | ENSP00000384364 | Prosaposin receptor GPR37; Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade; Belongs to the G-protein coupled receptor 1 family. | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | 0.575 |
GPR37 | NPY5R | ENSP00000306449 | ENSP00000423917 | Prosaposin receptor GPR37; Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade; Belongs to the G-protein coupled receptor 1 family. | Neuropeptide Y receptor type 5; Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. | 0.531 |
GPR37 | PNOC | ENSP00000306449 | ENSP00000301908 | Prosaposin receptor GPR37; Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade; Belongs to the G-protein coupled receptor 1 family. | Prepronociceptin; [Nociceptin]: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. [Orphanin FQ2]: Has potent analgesic activity. Belongs to the opioid neuropeptide precursor family. | 0.560 |
GPR37 | POMC | ENSP00000306449 | ENSP00000384092 | Prosaposin receptor GPR37; Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade; Belongs to the G-protein coupled receptor 1 family. | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. | 0.551 |
GPR37 | SST | ENSP00000306449 | ENSP00000287641 | Prosaposin receptor GPR37; Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade; Belongs to the G-protein coupled receptor 1 family. | Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin. | 0.544 |
INSL3 | NPBWR2 | ENSP00000369017 | ENSP00000358783 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family. | Neuropeptides B/W receptor type 2; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals; Belongs to the G-protein coupled receptor 1 family. | 0.652 |
INSL3 | POMC | ENSP00000369017 | ENSP00000384092 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family. | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. | 0.527 |
NPB | GPR37 | ENSP00000332766 | ENSP00000306449 | Neuropeptide B-23; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. | Prosaposin receptor GPR37; Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade; Belongs to the G-protein coupled receptor 1 family. | 0.523 |
NPB | NPBWR1 | ENSP00000332766 | ENSP00000330284 | Neuropeptide B-23; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B. | 0.999 |
NPB | NPBWR2 | ENSP00000332766 | ENSP00000358783 | Neuropeptide B-23; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. | Neuropeptides B/W receptor type 2; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals; Belongs to the G-protein coupled receptor 1 family. | 0.999 |
NPB | NPW | ENSP00000332766 | ENSP00000456974 | Neuropeptide B-23; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. | Neuropeptide W-23; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30. | 0.999 |
NPB | NPY | ENSP00000332766 | ENSP00000384364 | Neuropeptide B-23; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | 0.663 |
NPB | NPY5R | ENSP00000332766 | ENSP00000423917 | Neuropeptide B-23; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. | Neuropeptide Y receptor type 5; Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. | 0.502 |
NPB | PNOC | ENSP00000332766 | ENSP00000301908 | Neuropeptide B-23; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. | Prepronociceptin; [Nociceptin]: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. [Orphanin FQ2]: Has potent analgesic activity. Belongs to the opioid neuropeptide precursor family. | 0.591 |
NPB | POMC | ENSP00000332766 | ENSP00000384092 | Neuropeptide B-23; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. | 0.598 |
NPB | SST | ENSP00000332766 | ENSP00000287641 | Neuropeptide B-23; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. | Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin. | 0.605 |