node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CTTNBP2NL | MOB4 | ENSP00000271277 | ENSP00000315702 | CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like. | MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family. | 0.998 |
CTTNBP2NL | PDCD10 | ENSP00000271277 | ENSP00000376506 | CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like. | Programmed cell death protein 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Belongs to the PDCD10 family. | 0.998 |
CTTNBP2NL | PPP2CA | ENSP00000271277 | ENSP00000418447 | CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like. | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. | 0.996 |
CTTNBP2NL | PPP2R1A | ENSP00000271277 | ENSP00000324804 | CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like. | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis. | 0.997 |
CTTNBP2NL | STK25 | ENSP00000271277 | ENSP00000325748 | CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like. | Serine/threonine-protein kinase 25; Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. | 0.996 |
CTTNBP2NL | STK26 | ENSP00000271277 | ENSP00000377867 | CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like. | Serine/threonine-protein kinase 26; Mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. | 0.996 |
CTTNBP2NL | STRIP1 | ENSP00000271277 | ENSP00000358810 | CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like. | Striatin-interacting protein 1; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. | 0.999 |
CTTNBP2NL | STRN | ENSP00000271277 | ENSP00000263918 | CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like. | Striatin; Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling; Belongs to the WD repeat striatin family. | 0.997 |
CTTNBP2NL | STRN3 | ENSP00000271277 | ENSP00000350071 | CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like. | Striatin-3; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein. | 0.999 |
CTTNBP2NL | STRN4 | ENSP00000271277 | ENSP00000375777 | CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like. | Striatin-4; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein; Belongs to the WD repeat striatin family. | 0.998 |
MOB4 | CTTNBP2NL | ENSP00000315702 | ENSP00000271277 | MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family. | CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like. | 0.998 |
MOB4 | PDCD10 | ENSP00000315702 | ENSP00000376506 | MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family. | Programmed cell death protein 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Belongs to the PDCD10 family. | 0.999 |
MOB4 | PPP2CA | ENSP00000315702 | ENSP00000418447 | MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family. | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. | 0.999 |
MOB4 | PPP2R1A | ENSP00000315702 | ENSP00000324804 | MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family. | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis. | 0.999 |
MOB4 | STK25 | ENSP00000315702 | ENSP00000325748 | MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family. | Serine/threonine-protein kinase 25; Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. | 0.999 |
MOB4 | STK26 | ENSP00000315702 | ENSP00000377867 | MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family. | Serine/threonine-protein kinase 26; Mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. | 0.999 |
MOB4 | STRIP1 | ENSP00000315702 | ENSP00000358810 | MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family. | Striatin-interacting protein 1; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. | 0.999 |
MOB4 | STRN | ENSP00000315702 | ENSP00000263918 | MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family. | Striatin; Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling; Belongs to the WD repeat striatin family. | 0.999 |
MOB4 | STRN3 | ENSP00000315702 | ENSP00000350071 | MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family. | Striatin-3; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein. | 0.999 |
MOB4 | STRN4 | ENSP00000315702 | ENSP00000375777 | MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family. | Striatin-4; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein; Belongs to the WD repeat striatin family. | 0.999 |