node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABI1 | EPS8L3 | ENSP00000365312 | ENSP00000358820 | Abl interactor 1; May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl- mediated phosphorylation of ENAH. Recru [...] | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3. | 0.555 |
DSG4 | EPS8L3 | ENSP00000352785 | ENSP00000358820 | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity). | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3. | 0.491 |
DSG4 | SNRPE | ENSP00000352785 | ENSP00000400591 | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity). | Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. | 0.522 |
EPS8L3 | ABI1 | ENSP00000358820 | ENSP00000365312 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3. | Abl interactor 1; May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl- mediated phosphorylation of ENAH. Recru [...] | 0.555 |
EPS8L3 | DSG4 | ENSP00000358820 | ENSP00000352785 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3. | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity). | 0.491 |
EPS8L3 | ESPN | ENSP00000358820 | ENSP00000496593 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3. | Espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircas [...] | 0.608 |
EPS8L3 | IGSF23 | ENSP00000358820 | ENSP00000385592 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3. | Immunoglobulin superfamily member 23. | 0.450 |
EPS8L3 | MTSS2 | ENSP00000358820 | ENSP00000341171 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3. | Protein MTSS 2; Involved in plasma membrane dynamics. Potentiated PDGF- mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation. May function in actin bundling ; Belongs to the MTSS family. | 0.451 |
EPS8L3 | MUC13 | ENSP00000358820 | ENSP00000485028 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3. | Mucin-13; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling. | 0.521 |
EPS8L3 | RPL21 | ENSP00000358820 | ENSP00000346027 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3. | 60S ribosomal protein L21; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL21 family. | 0.471 |
EPS8L3 | SNRPE | ENSP00000358820 | ENSP00000400591 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3. | Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. | 0.497 |
EPS8L3 | USH1C | ENSP00000358820 | ENSP00000005226 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3. | Harmonin; USH1 protein network component harmonin. | 0.616 |
EPS8L3 | VIL1 | ENSP00000358820 | ENSP00000248444 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3. | Villin-1; Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the inte [...] | 0.446 |
ESPN | EPS8L3 | ENSP00000496593 | ENSP00000358820 | Espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircas [...] | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3. | 0.608 |
ESPN | USH1C | ENSP00000496593 | ENSP00000005226 | Espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircas [...] | Harmonin; USH1 protein network component harmonin. | 0.736 |
IGSF23 | EPS8L3 | ENSP00000385592 | ENSP00000358820 | Immunoglobulin superfamily member 23. | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3. | 0.450 |
MTSS2 | EPS8L3 | ENSP00000341171 | ENSP00000358820 | Protein MTSS 2; Involved in plasma membrane dynamics. Potentiated PDGF- mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation. May function in actin bundling ; Belongs to the MTSS family. | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3. | 0.451 |
MUC13 | EPS8L3 | ENSP00000485028 | ENSP00000358820 | Mucin-13; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling. | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3. | 0.521 |
MUC13 | VIL1 | ENSP00000485028 | ENSP00000248444 | Mucin-13; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling. | Villin-1; Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the inte [...] | 0.494 |
RPL21 | EPS8L3 | ENSP00000346027 | ENSP00000358820 | 60S ribosomal protein L21; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL21 family. | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3. | 0.471 |