node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGK | SFXN1 | ENSP00000497280 | ENSP00000316905 | Acylglycerol kinase, mitochondrial; Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Phosphorylates ceramide (By similarity). Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3- dioleoylglycerol (By similarity). Independently of its lipid kinase activity, acts as a component of the TIM22 complex. The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin- [...] | Sideroflexin-1; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Transports both D-serine and L-serine. Also able to transport other amino-acids, such as alanine. May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity); Belongs to the sideroflexi [...] | 0.413 |
AGK | SFXN2 | ENSP00000497280 | ENSP00000358909 | Acylglycerol kinase, mitochondrial; Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Phosphorylates ceramide (By similarity). Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3- dioleoylglycerol (By similarity). Independently of its lipid kinase activity, acts as a component of the TIM22 complex. The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin- [...] | Sideroflexin-2; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria. | 0.505 |
AGK | SFXN4 | ENSP00000497280 | ENSP00000347924 | Acylglycerol kinase, mitochondrial; Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Phosphorylates ceramide (By similarity). Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3- dioleoylglycerol (By similarity). Independently of its lipid kinase activity, acts as a component of the TIM22 complex. The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin- [...] | Sideroflexin-4; Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria. Belongs to the sideroflexin family. | 0.425 |
ATP5MD | SFXN2 | ENSP00000358840 | ENSP00000358909 | ATP synthase membrane subunit DAPIT, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism [...] | Sideroflexin-2; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria. | 0.441 |
DHODH | SFXN2 | ENSP00000219240 | ENSP00000358909 | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | Sideroflexin-2; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria. | 0.445 |
ENSP00000496197 | SFXN2 | ENSP00000496197 | ENSP00000358909 | Uncharacterized protein. | Sideroflexin-2; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria. | 0.475 |
MFSD13A | SFXN2 | ENSP00000238936 | ENSP00000358909 | Transmembrane protein 180; Major facilitator superfamily domain containing 13A. | Sideroflexin-2; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria. | 0.456 |
SFXN1 | AGK | ENSP00000316905 | ENSP00000497280 | Sideroflexin-1; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Transports both D-serine and L-serine. Also able to transport other amino-acids, such as alanine. May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity); Belongs to the sideroflexi [...] | Acylglycerol kinase, mitochondrial; Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Phosphorylates ceramide (By similarity). Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3- dioleoylglycerol (By similarity). Independently of its lipid kinase activity, acts as a component of the TIM22 complex. The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin- [...] | 0.413 |
SFXN1 | SFXN2 | ENSP00000316905 | ENSP00000358909 | Sideroflexin-1; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Transports both D-serine and L-serine. Also able to transport other amino-acids, such as alanine. May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity); Belongs to the sideroflexi [...] | Sideroflexin-2; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria. | 0.593 |
SFXN1 | SFXN4 | ENSP00000316905 | ENSP00000347924 | Sideroflexin-1; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Transports both D-serine and L-serine. Also able to transport other amino-acids, such as alanine. May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity); Belongs to the sideroflexi [...] | Sideroflexin-4; Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria. Belongs to the sideroflexin family. | 0.522 |
SFXN2 | AGK | ENSP00000358909 | ENSP00000497280 | Sideroflexin-2; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria. | Acylglycerol kinase, mitochondrial; Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Phosphorylates ceramide (By similarity). Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3- dioleoylglycerol (By similarity). Independently of its lipid kinase activity, acts as a component of the TIM22 complex. The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin- [...] | 0.505 |
SFXN2 | ATP5MD | ENSP00000358909 | ENSP00000358840 | Sideroflexin-2; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria. | ATP synthase membrane subunit DAPIT, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism [...] | 0.441 |
SFXN2 | DHODH | ENSP00000358909 | ENSP00000219240 | Sideroflexin-2; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria. | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | 0.445 |
SFXN2 | ENSP00000496197 | ENSP00000358909 | ENSP00000496197 | Sideroflexin-2; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria. | Uncharacterized protein. | 0.475 |
SFXN2 | MFSD13A | ENSP00000358909 | ENSP00000238936 | Sideroflexin-2; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria. | Transmembrane protein 180; Major facilitator superfamily domain containing 13A. | 0.456 |
SFXN2 | SFXN1 | ENSP00000358909 | ENSP00000316905 | Sideroflexin-2; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria. | Sideroflexin-1; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Transports both D-serine and L-serine. Also able to transport other amino-acids, such as alanine. May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity); Belongs to the sideroflexi [...] | 0.593 |
SFXN2 | SFXN4 | ENSP00000358909 | ENSP00000347924 | Sideroflexin-2; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria. | Sideroflexin-4; Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria. Belongs to the sideroflexin family. | 0.480 |
SFXN2 | SLC22A12 | ENSP00000358909 | ENSP00000366797 | Sideroflexin-2; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria. | Solute carrier family 22 member 12; Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | 0.466 |
SFXN2 | SPG7 | ENSP00000358909 | ENSP00000495795 | Sideroflexin-2; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria. | Paraplegin; ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function ; In the N-terminal section; belongs to the AAA ATPase family. | 0.602 |
SFXN2 | WBP1L | ENSP00000358909 | ENSP00000414721 | Sideroflexin-2; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria. | WW domain binding protein 1 like. | 0.462 |