node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMZ1 | CCDC57 | ENSP00000308149 | ENSP00000376154 | Archaemetzincin-1; Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2. Belongs to the peptidase M54 family. | Coiled-coil domain containing 57. | 0.521 |
AMZ1 | CMYA5 | ENSP00000308149 | ENSP00000394770 | Archaemetzincin-1; Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2. Belongs to the peptidase M54 family. | Cardiomyopathy-associated protein 5; May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin- mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). | 0.460 |
AMZ1 | DMRT3 | ENSP00000308149 | ENSP00000190165 | Archaemetzincin-1; Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2. Belongs to the peptidase M54 family. | Doublesex- and mab-3-related transcription factor 3; Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development (By similarity); Belongs to the DMRT family. | 0.456 |
AMZ1 | DNAJC12 | ENSP00000308149 | ENSP00000225171 | Archaemetzincin-1; Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2. Belongs to the peptidase M54 family. | DnaJ heat shock protein family member C12. | 0.459 |
AMZ1 | FAM111A | ENSP00000308149 | ENSP00000434435 | Archaemetzincin-1; Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2. Belongs to the peptidase M54 family. | Protein FAM111A; Chromatin-associated protein required for PCNA loading on replication sites. Promotes S-phase entry and DNA synthesis. May directly function at replication forks, explaining why Simian virus 40 (SV40) interacts with FAM111A to overcome host range restriction. | 0.472 |
AMZ1 | FASTKD3 | ENSP00000308149 | ENSP00000264669 | Archaemetzincin-1; Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2. Belongs to the peptidase M54 family. | FAST kinase domain-containing protein 3, mitochondrial; Required for normal mitochondrial respiration. Increases steady-state levels and half-lives of a subset of mature mitochondrial mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6. Promotes MT-CO1 mRNA translation and increases mitochondrial complex IV assembly and activity. | 0.519 |
AMZ1 | NKAIN4 | ENSP00000308149 | ENSP00000359340 | Archaemetzincin-1; Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2. Belongs to the peptidase M54 family. | Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4; Sodium/potassium transporting ATPase interacting 4; Belongs to the NKAIN family. | 0.519 |
AMZ1 | STK31 | ENSP00000308149 | ENSP00000348132 | Archaemetzincin-1; Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2. Belongs to the peptidase M54 family. | Serine/threonine kinase 31; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | 0.508 |
ATP1B1 | NKAIN4 | ENSP00000356790 | ENSP00000359340 | Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. | Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4; Sodium/potassium transporting ATPase interacting 4; Belongs to the NKAIN family. | 0.834 |
CCDC57 | AMZ1 | ENSP00000376154 | ENSP00000308149 | Coiled-coil domain containing 57. | Archaemetzincin-1; Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2. Belongs to the peptidase M54 family. | 0.521 |
CCDC57 | CMYA5 | ENSP00000376154 | ENSP00000394770 | Coiled-coil domain containing 57. | Cardiomyopathy-associated protein 5; May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin- mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). | 0.466 |
CCDC57 | DMRT3 | ENSP00000376154 | ENSP00000190165 | Coiled-coil domain containing 57. | Doublesex- and mab-3-related transcription factor 3; Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development (By similarity); Belongs to the DMRT family. | 0.440 |
CCDC57 | DNAJC12 | ENSP00000376154 | ENSP00000225171 | Coiled-coil domain containing 57. | DnaJ heat shock protein family member C12. | 0.448 |
CCDC57 | FAM111A | ENSP00000376154 | ENSP00000434435 | Coiled-coil domain containing 57. | Protein FAM111A; Chromatin-associated protein required for PCNA loading on replication sites. Promotes S-phase entry and DNA synthesis. May directly function at replication forks, explaining why Simian virus 40 (SV40) interacts with FAM111A to overcome host range restriction. | 0.454 |
CCDC57 | FASTKD3 | ENSP00000376154 | ENSP00000264669 | Coiled-coil domain containing 57. | FAST kinase domain-containing protein 3, mitochondrial; Required for normal mitochondrial respiration. Increases steady-state levels and half-lives of a subset of mature mitochondrial mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6. Promotes MT-CO1 mRNA translation and increases mitochondrial complex IV assembly and activity. | 0.491 |
CCDC57 | NKAIN4 | ENSP00000376154 | ENSP00000359340 | Coiled-coil domain containing 57. | Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4; Sodium/potassium transporting ATPase interacting 4; Belongs to the NKAIN family. | 0.473 |
CCDC57 | STK31 | ENSP00000376154 | ENSP00000348132 | Coiled-coil domain containing 57. | Serine/threonine kinase 31; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | 0.461 |
CMYA5 | AMZ1 | ENSP00000394770 | ENSP00000308149 | Cardiomyopathy-associated protein 5; May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin- mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). | Archaemetzincin-1; Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2. Belongs to the peptidase M54 family. | 0.460 |
CMYA5 | CCDC57 | ENSP00000394770 | ENSP00000376154 | Cardiomyopathy-associated protein 5; May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin- mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). | Coiled-coil domain containing 57. | 0.466 |
CMYA5 | DMRT3 | ENSP00000394770 | ENSP00000190165 | Cardiomyopathy-associated protein 5; May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin- mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). | Doublesex- and mab-3-related transcription factor 3; Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development (By similarity); Belongs to the DMRT family. | 0.408 |