Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
KHDC1KH homology domain-containing protein 1; KH domain containing 1; Belongs to the KHDC1 family. (237 aa)    
Predicted Functional Partners:
KHDC3L
KHDC3-like protein; KH domain containing 3 like, subcortical maternal complex member; Belongs to the KHDC1 family.
      
 0.977
DPPA5
Developmental pluripotency-associated 5 protein; Involved in the maintenance of embryonic stem (ES) cell pluripotency. Dispensable for self-renewal of pluripotent ES cells and establishment of germ cells. Associates with specific target mRNAs (By similarity); Belongs to the KHDC1 family.
      
 0.977
OOEP
Oocyte-expressed protein homolog; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the KHDC1 family.
   
  
 0.972
TRIM43
Tripartite motif containing 43.
      
 0.680
LEUTX
Leucine twenty homeobox.
      
 0.630
MBD3L2
methyl-CpG binding domain protein 3 like 2; Belongs to the MBD3L family.
   
  
 0.597
PRAMEF1
PRAME family member 1; Belongs to the PRAME family.
      
 0.593
PRAMEF2
PRAME family member 2; Belongs to the PRAME family.
      
 0.570
ZSCAN4
Zinc finger and SCAN domain-containing protein 4; Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).
      
 0.549
DUX4
Double homeobox protein 4-like protein 2; May be involved in transcriptional regulation.
      
 0.535
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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