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AFF2 protein (human) - STRING interaction network
"AFF2" - AF4/FMR2 family member 2 in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
AFF2AF4/FMR2 family member 2; RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure; AF4/FMR2 family (1311 aa)    
Predicted Functional Partners:
FMR1
Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Plays a role in the alternative splicing of its own mRNA. Plays a role in mRNA nuclear export (By similarity). Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons (By similarity). Stabilizes the scaffolding postsyna [...] (632 aa)
     
 
  0.846
TMEM185A
Transmembrane protein 185A; Belongs to the TMEM185 family (350 aa)
           
  0.804
TEX13A
Testis-expressed protein 13A; Zinc fingers RANBP2-type ; Belongs to the TEX13 family (409 aa)
           
  0.721
FRA10AC1
Protein FRA10AC1; FRA10A associated CGG repeat 1; Spliceosomal C complex (315 aa)
           
  0.720
CUL4B
Cullin-4B; Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and h [...] (913 aa)
           
  0.667
ARL13A
ADP-ribosylation factor-like protein 13A; ADP ribosylation factor like GTPase 13A; ARF GTPase family (256 aa)
           
  0.666
AKAP4
A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins (854 aa)
     
   
  0.652
CYLC1
Cylicin-1; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation (651 aa)
           
  0.650
ARHGEF6
Rho guanine nucleotide exchange factor 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF); Pleckstrin homology domain containing (776 aa)
     
   
  0.598
OPHN1
Oligophrenin-1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity); BAR-PH domain containing (802 aa)
           
  0.596
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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