STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FMR1NBFragile X mental retardation 1 neighbor protein; FMR1 neighbor. (255 aa)    
Predicted Functional Partners:
NXF2
Nuclear RNA export factor 2.
   
  
 0.662
NXF2B
Nuclear RNA export factor 2; Involved in the export of mRNA from the nucleus to the cytoplasm; Belongs to the NXF family.
   
  
 0.654
AFF2
AF4/FMR2 family member 2; RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure.
   
  
 0.613
CXorf51A
Uncharacterized protein CXorf51A; Chromosome X open reading frame 51A.
      
 0.582
SLITRK2
SLIT and NTRK-like protein 2; It is involved in synaptogenesis and promotes excitatory synapse differentiation. Suppresses neurite outgrowth (By similarity).
   
  
 0.578
HSFX4
Heat shock transcription factor family, X-linked member 4.
      
 0.542
FATE1
Fetal and adult testis-expressed transcript protein; Involved in the regulation of endoplasmic reticulum (ER)- mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis. May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling.
   
  
 0.530
CCDC83
Coiled-coil domain containing 83.
   
  
 0.529
FMR1
Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Plays a role in the alternative splicing of its own mRNA. Plays a role in mRNA nuclear export (By similarity). Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons (By similarity). Stabilizes the scaffolding postsyna [...]
   
  
 0.529
FAM209B
Protein FAM209B; Family with sequence similarity 209 member B.
      
 0.511
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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