FMR1NB protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

FMR1NB

Fragile X mental retardation 1 neighbor protein; FMR1 neighbor. (255 aa)

Predicted Functional Partners:

SPANXD

0.715

NRDC

0.651

SPANXC

0.646

SPANXA1

0.645

FAM209B

0.637

NXF2

0.635

NXF2B

0.634

SPINT3

0.632

CEBPZ

0.627

CWC22

0.609

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CEBPZ	FMR1NB	ENSP00000234170	ENSP00000359498	CCAAT/enhancer-binding protein zeta; Stimulates transcription from the HSP70 promoter; Belongs to the CBF/MAK21 family.	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor.	0.627
CWC22	FMR1NB	ENSP00000387006	ENSP00000359498	Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Belongs to the CWC22 family.	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor.	0.609
FAM209B	FMR1NB	ENSP00000360376	ENSP00000359498	Protein FAM209B; Family with sequence similarity 209 member B.	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor.	0.637
FMR1NB	CEBPZ	ENSP00000359498	ENSP00000234170	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor.	CCAAT/enhancer-binding protein zeta; Stimulates transcription from the HSP70 promoter; Belongs to the CBF/MAK21 family.	0.627
FMR1NB	CWC22	ENSP00000359498	ENSP00000387006	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor.	Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Belongs to the CWC22 family.	0.609
FMR1NB	FAM209B	ENSP00000359498	ENSP00000360376	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor.	Protein FAM209B; Family with sequence similarity 209 member B.	0.637
FMR1NB	NRDC	ENSP00000359498	ENSP00000346890	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor.	Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs; Belongs to the peptidase M16 family.	0.651
FMR1NB	NXF2	ENSP00000359498	ENSP00000485586	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor.	Nuclear RNA export factor 2.	0.635
FMR1NB	NXF2B	ENSP00000359498	ENSP00000472530	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor.	Nuclear RNA export factor 2; Involved in the export of mRNA from the nucleus to the cytoplasm; Belongs to the NXF family.	0.634
FMR1NB	SPANXA1	ENSP00000359498	ENSP00000359550	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor.	Sperm protein associated with the nucleus, X-linked, family member A1.	0.645
FMR1NB	SPANXC	ENSP00000359498	ENSP00000351884	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor.	Sperm protein associated with the nucleus on the X chromosome C; SPANX family member C; Belongs to the SPAN-X family.	0.646
FMR1NB	SPANXD	ENSP00000359498	ENSP00000359546	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor.	Sperm protein associated with the nucleus on the X chromosome D; SPANX family member D; Belongs to the SPAN-X family.	0.715
FMR1NB	SPINT3	ENSP00000359498	ENSP00000217428	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor.	Serine peptidase inhibitor, Kunitz type 3.	0.632
NRDC	FMR1NB	ENSP00000346890	ENSP00000359498	Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs; Belongs to the peptidase M16 family.	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor.	0.651
NXF2	FMR1NB	ENSP00000485586	ENSP00000359498	Nuclear RNA export factor 2.	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor.	0.635
NXF2	NXF2B	ENSP00000485586	ENSP00000472530	Nuclear RNA export factor 2.	Nuclear RNA export factor 2; Involved in the export of mRNA from the nucleus to the cytoplasm; Belongs to the NXF family.	0.978
NXF2B	FMR1NB	ENSP00000472530	ENSP00000359498	Nuclear RNA export factor 2; Involved in the export of mRNA from the nucleus to the cytoplasm; Belongs to the NXF family.	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor.	0.634
NXF2B	NXF2	ENSP00000472530	ENSP00000485586	Nuclear RNA export factor 2; Involved in the export of mRNA from the nucleus to the cytoplasm; Belongs to the NXF family.	Nuclear RNA export factor 2.	0.978
SPANXA1	FMR1NB	ENSP00000359550	ENSP00000359498	Sperm protein associated with the nucleus, X-linked, family member A1.	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor.	0.645
SPANXA1	SPANXC	ENSP00000359550	ENSP00000351884	Sperm protein associated with the nucleus, X-linked, family member A1.	Sperm protein associated with the nucleus on the X chromosome C; SPANX family member C; Belongs to the SPAN-X family.	0.978