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NTSR1 protein (human) - STRING interaction network
"NTSR1" - Neurotensin receptor 1 (high affinity) in Homo sapiens
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Predicted Interactions
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NTSR1Neurotensin receptor 1 (high affinity); G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed-8381365, PubMed-21725197, PubMed-23140271). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed-21725197) (418 aa)    
Predicted Functional Partners:
NTS
Neurotensin; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle (170 aa)
       
  0.985
ADRBK1
Adrenergic, beta, receptor kinase 1; Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (689 aa)
       
  0.946
OXTR
Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol- calcium second messenger system (389 aa)
         
  0.941
KALRN
Kalirin, RhoGEF kinase; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity (1663 aa)
         
  0.941
NMU
Neuromedin U; Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder (174 aa)
     
  0.932
F2R
Coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development (425 aa)
         
  0.931
GNRH1
Gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones (92 aa)
     
 
  0.927
GCGR
Glucagon receptor; G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signal [...] (477 aa)
     
 
  0.924
OXT
Oxytocin/neurophysin I prepropeptide; Neurophysin 1 specifically binds oxytocin (125 aa)
         
  0.923
F2
Coagulation factor II (thrombin); Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (622 aa)
         
  0.921
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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