Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SPANXDSperm protein associated with the nucleus on the X chromosome D; SPANX family member D; Belongs to the SPAN-X family. (97 aa)    
Predicted Functional Partners:
SPANXB1
Sperm protein associated with the nucleus on the X chromosome B1; SPANX family member B1.
   
 
0.959
SPANXC
Sperm protein associated with the nucleus on the X chromosome C; SPANX family member C; Belongs to the SPAN-X family.
   
   
0.952
SPANXA1
Sperm protein associated with the nucleus, X-linked, family member A1.
   
  
0.944
SETBP1
SET binding protein 1.
    
   0.803
ROPN1B
Ropporin-1B; Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation. Belongs to the ropporin family.
   
   0.742
ROPN1
Ropporin-1A; Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation. Belongs to the ropporin family.
   
   0.737
FMR1NB
Fragile X mental retardation 1 neighbor protein; FMR1 neighbor.
   
  
 0.715
ADAM7
Disintegrin and metalloproteinase domain-containing protein 7; May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity).
   
    0.683
SPACA1
Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis (By similarity). Important for male fertility.
   
  
 0.655
NUP210L
Nuclear pore membrane glycoprotein 210-like; Nucleoporin 210 like; Belongs to the NUP210 family.
   
    0.646
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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