Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
SPANXA1Sperm protein associated with the nucleus, X-linked, family member A1. (97 aa)    
Predicted Functional Partners:
SPANXC
Sperm protein associated with the nucleus on the X chromosome C; SPANX family member C; Belongs to the SPAN-X family.
   
  
0.978
SPANXA2
Sperm protein associated with the nucleus on the X chromosome A; SPANX family member A2; Belongs to the SPAN-X family.
   
   
0.978
SPANXB1
Sperm protein associated with the nucleus on the X chromosome B1; SPANX family member B1.
   
  
0.978
SPANXD
Sperm protein associated with the nucleus on the X chromosome D; SPANX family member D; Belongs to the SPAN-X family.
   
  
0.944
AKAP4
A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; Belongs to the AKAP110 family.
   
  
 0.906
SPANXN4
Sperm protein associated with the nucleus on the X chromosome N4; SPANX family member N4; Belongs to the SPAN-X family.
   
  
 0.880
ROPN1
Ropporin-1A; Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation. Belongs to the ropporin family.
   
 
 0.838
ROPN1B
Ropporin-1B; Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation. Belongs to the ropporin family.
   
   0.743
TEKT4
Tektin-4; May be a structural component of the sperm flagellum. Contributes to normal sperm motility; Belongs to the tektin family.
   
  
 0.728
TSN
Translin; DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots; Belongs to the translin family.
      
 0.725
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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