node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FAM209B | PHACTR3 | ENSP00000360376 | ENSP00000360054 | Protein FAM209B; Family with sequence similarity 209 member B. | Phosphatase and actin regulator 3. | 0.437 |
HS3ST2 | PHACTR3 | ENSP00000261374 | ENSP00000360054 | Heparan sulfate glucosamine 3-O-sulfotransferase 2; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. | Phosphatase and actin regulator 3. | 0.463 |
HS3ST2 | TAFA4 | ENSP00000261374 | ENSP00000295569 | Heparan sulfate glucosamine 3-O-sulfotransferase 2; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. | Chemokine-like protein TAFA-4; Modulates injury-induced and chemical pain hypersensitivity (By similarity). Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release. Belongs to the TAFA family. | 0.431 |
PEPD | PHACTR3 | ENSP00000244137 | ENSP00000360054 | Xaa-Pro dipeptidase; Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen; Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily. | Phosphatase and actin regulator 3. | 0.427 |
PHACTR3 | FAM209B | ENSP00000360054 | ENSP00000360376 | Phosphatase and actin regulator 3. | Protein FAM209B; Family with sequence similarity 209 member B. | 0.437 |
PHACTR3 | HS3ST2 | ENSP00000360054 | ENSP00000261374 | Phosphatase and actin regulator 3. | Heparan sulfate glucosamine 3-O-sulfotransferase 2; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. | 0.463 |
PHACTR3 | PEPD | ENSP00000360054 | ENSP00000244137 | Phosphatase and actin regulator 3. | Xaa-Pro dipeptidase; Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen; Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily. | 0.427 |
PHACTR3 | PHYHIPL | ENSP00000360054 | ENSP00000362987 | Phosphatase and actin regulator 3. | Phytanoyl-CoA hydroxylase-interacting protein-like; May play a role in the development of the central system. | 0.522 |
PHACTR3 | PPP1CA | ENSP00000360054 | ENSP00000326031 | Phosphatase and actin regulator 3. | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] | 0.888 |
PHACTR3 | PRDM14 | ENSP00000360054 | ENSP00000276594 | Phosphatase and actin regulator 3. | PR domain zinc finger protein 14; Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up- regulates the e [...] | 0.513 |
PHACTR3 | SIDT2 | ENSP00000360054 | ENSP00000314023 | Phosphatase and actin regulator 3. | SID1 transmembrane family member 2; Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP- dependent manner, and degraded. Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis. Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis. In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward R [...] | 0.435 |
PHACTR3 | SMIM17 | ENSP00000360054 | ENSP00000471126 | Phosphatase and actin regulator 3. | Small integral membrane protein 17. | 0.490 |
PHACTR3 | TAFA4 | ENSP00000360054 | ENSP00000295569 | Phosphatase and actin regulator 3. | Chemokine-like protein TAFA-4; Modulates injury-induced and chemical pain hypersensitivity (By similarity). Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release. Belongs to the TAFA family. | 0.730 |
PHACTR3 | TMA16 | ENSP00000360054 | ENSP00000351380 | Phosphatase and actin regulator 3. | Translation machinery associated 16 homolog. | 0.528 |
PHYHIPL | PHACTR3 | ENSP00000362987 | ENSP00000360054 | Phytanoyl-CoA hydroxylase-interacting protein-like; May play a role in the development of the central system. | Phosphatase and actin regulator 3. | 0.522 |
PHYHIPL | TMA16 | ENSP00000362987 | ENSP00000351380 | Phytanoyl-CoA hydroxylase-interacting protein-like; May play a role in the development of the central system. | Translation machinery associated 16 homolog. | 0.585 |
PPP1CA | PHACTR3 | ENSP00000326031 | ENSP00000360054 | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] | Phosphatase and actin regulator 3. | 0.888 |
PRDM14 | PHACTR3 | ENSP00000276594 | ENSP00000360054 | PR domain zinc finger protein 14; Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up- regulates the e [...] | Phosphatase and actin regulator 3. | 0.513 |
PRDM14 | TAFA4 | ENSP00000276594 | ENSP00000295569 | PR domain zinc finger protein 14; Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up- regulates the e [...] | Chemokine-like protein TAFA-4; Modulates injury-induced and chemical pain hypersensitivity (By similarity). Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release. Belongs to the TAFA family. | 0.514 |
SIDT2 | PHACTR3 | ENSP00000314023 | ENSP00000360054 | SID1 transmembrane family member 2; Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP- dependent manner, and degraded. Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis. Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis. In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward R [...] | Phosphatase and actin regulator 3. | 0.435 |