STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACTRT1Actin related protein t1; Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression (376 aa)    
Predicted Functional Partners:
TCP11X2
T-complex protein 11 x-linked protein 2; T-complex 11 family, X-linked 2; Belongs to the TCP11 family
      
 0.704
PRR32
Proline-rich protein 32; Proline rich 32
      
 0.661
RALYL
RNA-binding Raly-like protein; RALY RNA binding protein like
    
 
 0.655
SPACA5
Sperm acrosome-associated protein 5; Sperm acrosome associated 5; Belongs to the glycosyl hydrolase 22 family
   
  
 0.640
SPACA5B
Sperm acrosome associated 5B; Lysozymes, c-type
   
  
 0.639
SHE
SH2 domain-containing adapter protein E; Src homology 2 domain containing E
      
 0.636
CCIN
Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation; BTB domain containing
   
 
 0.635
CFL1
Cofilin-1; Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration (By similarity)
   
 
 0.614
LRRC39
Leucine-rich repeat-containing protein 39; Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart
    
 
 0.611
WSCD2
Wsc domain-containing protein 2; WSC domain containing 2; Belongs to the WSCD family
    
 
 0.583
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.