Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
TMEM61Transmembrane protein 61. (210 aa)    
Predicted Functional Partners:
BSND
Barttin; Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter.
 
 
  
 0.508
TMEM74B
Transmembrane protein 74B.
  
  
 0.474
DYDC1
DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis.
      
 0.468
TMEM156
Transmembrane protein 156.
  
   
 0.467
TMEM213
Transmembrane protein 213.
   
  
 0.460
SLC22A18
Solute carrier family 22 member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
   
    0.459
DYDC2
DPY30 domain containing 2; Belongs to the dpy-30 family.
   
  
 0.441
TMEM239
Transmembrane protein 239.
      
 0.435
TMEM116
Transmembrane protein 116.
   
  
 0.428
MUCL3
Mucin-like protein 3; May modulate NF-kappaB signaling and play a role in cell growth.
   
    0.402
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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