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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FAM209AProtein FAM209A; Family with sequence similarity 209 member A. (171 aa)    
Predicted Functional Partners:
TMCO5A
Transmembrane and coiled-coil domains 5A; Belongs to the TMCO5 family.
      
 0.705
C9orf43
Uncharacterized protein C9orf43; Chromosome 9 open reading frame 43.
      
 0.667
C9orf131
Uncharacterized protein C9orf131; Chromosome 9 open reading frame 131.
      
 0.646
C12orf40
Uncharacterized protein C12orf40; Chromosome 12 open reading frame 40.
      
 0.626
SPATA16
Spermatogenesis-associated protein 16; Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion.
      
 0.626
MAGEB16
Melanoma-associated antigen B16; MAGE family member B16.
      
 0.625
ZFAND4
Zinc finger AN1-type containing 4.
   
  
 0.590
TULP2
TUB like protein 2; Belongs to the TUB family.
   
  
 0.573
UBASH3B
Ubiquitin-associated and SH3 domain-containing protein B; Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
    
   0.571
PKDREJ
Polycystic kidney disease and receptor for egg jelly-related protein; May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm; Belongs to the polycystin family.
   
  
 0.568
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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