node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CBY1 | TSHZ2 | ENSP00000478962 | ENSP00000360552 | Protein chibby homolog 1; Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. Belongs to the chibby family. | Teashirt homolog 2; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Belongs to the teashirt C2H2-type zinc-finger protein family. | 0.453 |
EXD1 | TSHZ2 | ENSP00000415056 | ENSP00000360552 | piRNA biogenesis protein EXD1; RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loa [...] | Teashirt homolog 2; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Belongs to the teashirt C2H2-type zinc-finger protein family. | 0.438 |
GLI1 | TSHZ2 | ENSP00000228682 | ENSP00000360552 | Zinc finger protein GLI1; Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling. Belongs to the GLI C2H2-type zinc-finger protein family. | Teashirt homolog 2; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Belongs to the teashirt C2H2-type zinc-finger protein family. | 0.493 |
HOXA7 | LGALS4 | ENSP00000242159 | ENSP00000302100 | Homeobox protein Hox-A7; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. | Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions. | 0.507 |
HOXA7 | TSHZ2 | ENSP00000242159 | ENSP00000360552 | Homeobox protein Hox-A7; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. | Teashirt homolog 2; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Belongs to the teashirt C2H2-type zinc-finger protein family. | 0.455 |
LGALS4 | HOXA7 | ENSP00000302100 | ENSP00000242159 | Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions. | Homeobox protein Hox-A7; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. | 0.507 |
LGALS4 | TSHZ2 | ENSP00000302100 | ENSP00000360552 | Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions. | Teashirt homolog 2; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Belongs to the teashirt C2H2-type zinc-finger protein family. | 0.488 |
LGALS4 | ZFHX2 | ENSP00000302100 | ENSP00000413418 | Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions. | Zinc finger homeobox protein 2; Transcriptional regulator that is critical for the regulation of pain perception and processing of noxious stimuli. | 0.416 |
SMARCE1 | TSHZ2 | ENSP00000323967 | ENSP00000360552 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). Du [...] | Teashirt homolog 2; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Belongs to the teashirt C2H2-type zinc-finger protein family. | 0.442 |
TSHZ2 | CBY1 | ENSP00000360552 | ENSP00000478962 | Teashirt homolog 2; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Belongs to the teashirt C2H2-type zinc-finger protein family. | Protein chibby homolog 1; Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. Belongs to the chibby family. | 0.453 |
TSHZ2 | EXD1 | ENSP00000360552 | ENSP00000415056 | Teashirt homolog 2; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Belongs to the teashirt C2H2-type zinc-finger protein family. | piRNA biogenesis protein EXD1; RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loa [...] | 0.438 |
TSHZ2 | GLI1 | ENSP00000360552 | ENSP00000228682 | Teashirt homolog 2; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Belongs to the teashirt C2H2-type zinc-finger protein family. | Zinc finger protein GLI1; Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling. Belongs to the GLI C2H2-type zinc-finger protein family. | 0.493 |
TSHZ2 | HOXA7 | ENSP00000360552 | ENSP00000242159 | Teashirt homolog 2; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Belongs to the teashirt C2H2-type zinc-finger protein family. | Homeobox protein Hox-A7; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. | 0.455 |
TSHZ2 | LGALS4 | ENSP00000360552 | ENSP00000302100 | Teashirt homolog 2; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Belongs to the teashirt C2H2-type zinc-finger protein family. | Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions. | 0.488 |
TSHZ2 | SMARCE1 | ENSP00000360552 | ENSP00000323967 | Teashirt homolog 2; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Belongs to the teashirt C2H2-type zinc-finger protein family. | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). Du [...] | 0.442 |
TSHZ2 | ZFHX2 | ENSP00000360552 | ENSP00000413418 | Teashirt homolog 2; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Belongs to the teashirt C2H2-type zinc-finger protein family. | Zinc finger homeobox protein 2; Transcriptional regulator that is critical for the regulation of pain perception and processing of noxious stimuli. | 0.423 |
ZFHX2 | LGALS4 | ENSP00000413418 | ENSP00000302100 | Zinc finger homeobox protein 2; Transcriptional regulator that is critical for the regulation of pain perception and processing of noxious stimuli. | Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions. | 0.416 |
ZFHX2 | TSHZ2 | ENSP00000413418 | ENSP00000360552 | Zinc finger homeobox protein 2; Transcriptional regulator that is critical for the regulation of pain perception and processing of noxious stimuli. | Teashirt homolog 2; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Belongs to the teashirt C2H2-type zinc-finger protein family. | 0.423 |