DIPK1B protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC123	DIPK1B	ENSP00000281141	ENSP00000360757	Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle.	Divergent protein kinase domain 1B; Belongs to the DIPK family.	0.469
DIPK1A	DIPK1B	ENSP00000359333	ENSP00000360757	Divergent protein kinase domain 1A.	Divergent protein kinase domain 1B; Belongs to the DIPK family.	0.666
DIPK1A	DIPK2B	ENSP00000359333	ENSP00000381086	Divergent protein kinase domain 1A.	Divergent protein kinase domain 2B.	0.575
DIPK1B	CDC123	ENSP00000360757	ENSP00000281141	Divergent protein kinase domain 1B; Belongs to the DIPK family.	Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle.	0.469
DIPK1B	DIPK1A	ENSP00000360757	ENSP00000359333	Divergent protein kinase domain 1B; Belongs to the DIPK family.	Divergent protein kinase domain 1A.	0.666
DIPK1B	DIPK2B	ENSP00000360757	ENSP00000381086	Divergent protein kinase domain 1B; Belongs to the DIPK family.	Divergent protein kinase domain 2B.	0.458
DIPK1B	LRRC52	ENSP00000360757	ENSP00000294818	Divergent protein kinase domain 1B; Belongs to the DIPK family.	Leucine-rich repeat-containing protein 52; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. KCNU1 channel auxiliary protein. May modulate KCNU1 gating properties.	0.818
DIPK1B	SAT1	ENSP00000360757	ENSP00000368572	Divergent protein kinase domain 1B; Belongs to the DIPK family.	Diamine acetyltransferase 1; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)- acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine; Belongs to the acetyltransferase family.	0.674
DIPK1B	XPO7	ENSP00000360757	ENSP00000252512	Divergent protein kinase domain 1B; Belongs to the DIPK family.	Exportin-7; Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate ano [...]	0.457
DIPK2B	DIPK1A	ENSP00000381086	ENSP00000359333	Divergent protein kinase domain 2B.	Divergent protein kinase domain 1A.	0.575
DIPK2B	DIPK1B	ENSP00000381086	ENSP00000360757	Divergent protein kinase domain 2B.	Divergent protein kinase domain 1B; Belongs to the DIPK family.	0.458
LRRC52	DIPK1B	ENSP00000294818	ENSP00000360757	Leucine-rich repeat-containing protein 52; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. KCNU1 channel auxiliary protein. May modulate KCNU1 gating properties.	Divergent protein kinase domain 1B; Belongs to the DIPK family.	0.818
SAT1	DIPK1B	ENSP00000368572	ENSP00000360757	Diamine acetyltransferase 1; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)- acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine; Belongs to the acetyltransferase family.	Divergent protein kinase domain 1B; Belongs to the DIPK family.	0.674
XPO7	DIPK1B	ENSP00000252512	ENSP00000360757	Exportin-7; Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate ano [...]	Divergent protein kinase domain 1B; Belongs to the DIPK family.	0.457