node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BEST4 | C11orf86 | ENSP00000361281 | ENSP00000311479 | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | Uncharacterized protein C11orf86; Chromosome 11 open reading frame 86. | 0.449 |
BEST4 | CA7 | ENSP00000361281 | ENSP00000345659 | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | Carbonic anhydrase 7; Reversible hydration of carbon dioxide; Belongs to the alpha-carbonic anhydrase family. | 0.457 |
BEST4 | CNGA2 | ENSP00000361281 | ENSP00000328478 | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | Cyclic nucleotide-gated olfactory channel; Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily. | 0.427 |
BEST4 | GLUL | ENSP00000361281 | ENSP00000307900 | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine. Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane locali [...] | 0.489 |
BEST4 | GUCA2B | ENSP00000361281 | ENSP00000361662 | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | Guanylate cyclase C-activating peptide 2; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. | 0.471 |
BEST4 | LGSN | ENSP00000361281 | ENSP00000359691 | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | Lengsin; May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity); Belongs to the glutamine synthetase family. | 0.412 |
BEST4 | OTOP2 | ENSP00000361281 | ENSP00000332528 | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | Proton channel OTOP2; Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. Belongs to the otopetrin family. | 0.746 |
BEST4 | PELO | ENSP00000361281 | ENSP00000274311 | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | Protein pelota homolog; Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). Belongs to the eukaryotic release factor 1 family. Pelota subfamily. | 0.549 |
BEST4 | TMEM82 | ENSP00000361281 | ENSP00000364938 | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | Transmembrane protein 82. | 0.451 |
BEST4 | TMIGD1 | ENSP00000361281 | ENSP00000332404 | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | Transmembrane and immunoglobulin domain-containing protein 1; May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival. | 0.429 |
C11orf86 | BEST4 | ENSP00000311479 | ENSP00000361281 | Uncharacterized protein C11orf86; Chromosome 11 open reading frame 86. | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | 0.449 |
CA7 | BEST4 | ENSP00000345659 | ENSP00000361281 | Carbonic anhydrase 7; Reversible hydration of carbon dioxide; Belongs to the alpha-carbonic anhydrase family. | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | 0.457 |
CA7 | OTOP2 | ENSP00000345659 | ENSP00000332528 | Carbonic anhydrase 7; Reversible hydration of carbon dioxide; Belongs to the alpha-carbonic anhydrase family. | Proton channel OTOP2; Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. Belongs to the otopetrin family. | 0.418 |
CNGA2 | BEST4 | ENSP00000328478 | ENSP00000361281 | Cyclic nucleotide-gated olfactory channel; Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily. | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | 0.427 |
GLUL | BEST4 | ENSP00000307900 | ENSP00000361281 | Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine. Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane locali [...] | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | 0.489 |
GLUL | LGSN | ENSP00000307900 | ENSP00000359691 | Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine. Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane locali [...] | Lengsin; May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity); Belongs to the glutamine synthetase family. | 0.940 |
GUCA2B | BEST4 | ENSP00000361662 | ENSP00000361281 | Guanylate cyclase C-activating peptide 2; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | 0.471 |
GUCA2B | OTOP2 | ENSP00000361662 | ENSP00000332528 | Guanylate cyclase C-activating peptide 2; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. | Proton channel OTOP2; Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. Belongs to the otopetrin family. | 0.596 |
GUCA2B | TMEM82 | ENSP00000361662 | ENSP00000364938 | Guanylate cyclase C-activating peptide 2; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. | Transmembrane protein 82. | 0.496 |
GUCA2B | TMIGD1 | ENSP00000361662 | ENSP00000332404 | Guanylate cyclase C-activating peptide 2; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. | Transmembrane and immunoglobulin domain-containing protein 1; May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival. | 0.677 |