node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C9orf78 | CDC40 | ENSP00000361524 | ENSP00000357928 | Telomere length and silencing protein 1 homolog; Involved in the regulation of telomeric heterochromatin assembly and control of telomere length. Belongs to the TLS1 family. | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | 0.819 |
C9orf78 | DHX35 | ENSP00000361524 | ENSP00000252011 | Telomere length and silencing protein 1 homolog; Involved in the regulation of telomeric heterochromatin assembly and control of telomere length. Belongs to the TLS1 family. | Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. | 0.757 |
C9orf78 | EFTUD2 | ENSP00000361524 | ENSP00000392094 | Telomere length and silencing protein 1 homolog; Involved in the regulation of telomeric heterochromatin assembly and control of telomere length. Belongs to the TLS1 family. | 116 kDa U5 small nuclear ribonucleoprotein component; Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. | 0.738 |
C9orf78 | MED22 | ENSP00000361524 | ENSP00000482438 | Telomere length and silencing protein 1 homolog; Involved in the regulation of telomeric heterochromatin assembly and control of telomere length. Belongs to the TLS1 family. | Mediator of RNA polymerase II transcription subunit 22; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.806 |
C9orf78 | PPIL1 | ENSP00000361524 | ENSP00000362803 | Telomere length and silencing protein 1 homolog; Involved in the regulation of telomeric heterochromatin assembly and control of telomere length. Belongs to the TLS1 family. | Peptidyl-prolyl cis-trans isomerase-like 1; Involved in pre-mRNA splicing as component of the spliceosome. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily. | 0.802 |
C9orf78 | PRPF38A | ENSP00000361524 | ENSP00000257181 | Telomere length and silencing protein 1 homolog; Involved in the regulation of telomeric heterochromatin assembly and control of telomere length. Belongs to the TLS1 family. | Pre-mRNA-splicing factor 38A; Involved in pre-mRNA splicing as a component of the spliceosome. | 0.793 |
C9orf78 | PRPF8 | ENSP00000361524 | ENSP00000460348 | Telomere length and silencing protein 1 homolog; Involved in the regulation of telomeric heterochromatin assembly and control of telomere length. Belongs to the TLS1 family. | Pre-mRNA-processing-splicing factor 8; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both t [...] | 0.951 |
C9orf78 | SLU7 | ENSP00000361524 | ENSP00000297151 | Telomere length and silencing protein 1 homolog; Involved in the regulation of telomeric heterochromatin assembly and control of telomere length. Belongs to the TLS1 family. | Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. | 0.879 |
C9orf78 | SNRNP200 | ENSP00000361524 | ENSP00000317123 | Telomere length and silencing protein 1 homolog; Involved in the regulation of telomeric heterochromatin assembly and control of telomere length. Belongs to the TLS1 family. | U5 small nuclear ribonucleoprotein 200 kDa helicase; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. | 0.971 |
C9orf78 | SYF2 | ENSP00000361524 | ENSP00000236273 | Telomere length and silencing protein 1 homolog; Involved in the regulation of telomeric heterochromatin assembly and control of telomere length. Belongs to the TLS1 family. | Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the SYF2 family. | 0.881 |
CDC40 | C9orf78 | ENSP00000357928 | ENSP00000361524 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Telomere length and silencing protein 1 homolog; Involved in the regulation of telomeric heterochromatin assembly and control of telomere length. Belongs to the TLS1 family. | 0.819 |
CDC40 | DHX35 | ENSP00000357928 | ENSP00000252011 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. | 0.843 |
CDC40 | EFTUD2 | ENSP00000357928 | ENSP00000392094 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | 116 kDa U5 small nuclear ribonucleoprotein component; Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. | 0.999 |
CDC40 | PPIL1 | ENSP00000357928 | ENSP00000362803 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Peptidyl-prolyl cis-trans isomerase-like 1; Involved in pre-mRNA splicing as component of the spliceosome. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily. | 0.999 |
CDC40 | PRPF38A | ENSP00000357928 | ENSP00000257181 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Pre-mRNA-splicing factor 38A; Involved in pre-mRNA splicing as a component of the spliceosome. | 0.974 |
CDC40 | PRPF8 | ENSP00000357928 | ENSP00000460348 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Pre-mRNA-processing-splicing factor 8; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both t [...] | 0.999 |
CDC40 | SLU7 | ENSP00000357928 | ENSP00000297151 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. | 0.999 |
CDC40 | SNRNP200 | ENSP00000357928 | ENSP00000317123 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | U5 small nuclear ribonucleoprotein 200 kDa helicase; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. | 0.996 |
CDC40 | SYF2 | ENSP00000357928 | ENSP00000236273 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the SYF2 family. | 0.999 |
DHX35 | C9orf78 | ENSP00000252011 | ENSP00000361524 | Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. | Telomere length and silencing protein 1 homolog; Involved in the regulation of telomeric heterochromatin assembly and control of telomere length. Belongs to the TLS1 family. | 0.757 |