STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF684Zinc finger protein 684; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (378 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]
   
  0.659
CCDC17
Coiled-coil domain containing 17.
   
 
 0.650
FBXO48
F-box protein 48.
   
  
 0.624
OR5AP2
Olfactory receptor 5AP2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.579
OR8B4
Olfactory receptor 8B4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.574
FOXD4L6
Forkhead box D4 like 6.
    
 
 0.569
PHETA1
Sesquipedalian-1; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
    
 
 0.544
OR1L8
Olfactory receptor 1L8; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.543
BHLHA9
Class A basic helix-loop-helix protein 9; Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis.
      
 0.510
OR2I1P
Putative olfactory receptor 2I1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.495
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.