node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEBP1 | TP53TG5 | ENSP00000223357 | ENSP00000361811 | Adipocyte enhancer-binding protein 1; [Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix; Belongs to the peptidase M14 family. | TP53-target gene 5 protein; May play a significant role in p53/TP53-mediating signaling pathway. | 0.433 |
C16orf90 | TP53TG5 | ENSP00000401335 | ENSP00000361811 | Uncharacterized protein C16orf90; Chromosome 16 open reading frame 90. | TP53-target gene 5 protein; May play a significant role in p53/TP53-mediating signaling pathway. | 0.447 |
FNTA | TP53TG5 | ENSP00000303423 | ENSP00000361811 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic- aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. | TP53-target gene 5 protein; May play a significant role in p53/TP53-mediating signaling pathway. | 0.420 |
MADD | TP53TG5 | ENSP00000310933 | ENSP00000361811 | MAP kinase-activating death domain protein; Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is res [...] | TP53-target gene 5 protein; May play a significant role in p53/TP53-mediating signaling pathway. | 0.441 |
PSME3IP1 | TP53TG5 | ENSP00000335808 | ENSP00000361811 | PSME3-interacting protein; Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus. | TP53-target gene 5 protein; May play a significant role in p53/TP53-mediating signaling pathway. | 0.538 |
SYS1 | TP53TG5 | ENSP00000243918 | ENSP00000361811 | Protein SYS1 homolog; Involved in protein trafficking. May serve as a receptor for ARFRP1; Belongs to the SYS1 family. | TP53-target gene 5 protein; May play a significant role in p53/TP53-mediating signaling pathway. | 0.510 |
TP53I11 | TP53I13 | ENSP00000436152 | ENSP00000301057 | Tumor protein p53 inducible protein 11. | Tumor protein p53-inducible protein 13; May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed. | 0.402 |
TP53I11 | TP53TG5 | ENSP00000436152 | ENSP00000361811 | Tumor protein p53 inducible protein 11. | TP53-target gene 5 protein; May play a significant role in p53/TP53-mediating signaling pathway. | 0.491 |
TP53I13 | TP53I11 | ENSP00000301057 | ENSP00000436152 | Tumor protein p53-inducible protein 13; May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed. | Tumor protein p53 inducible protein 11. | 0.402 |
TP53I13 | TP53TG5 | ENSP00000301057 | ENSP00000361811 | Tumor protein p53-inducible protein 13; May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed. | TP53-target gene 5 protein; May play a significant role in p53/TP53-mediating signaling pathway. | 0.432 |
TP53RK | TP53TG5 | ENSP00000361186 | ENSP00000361811 | EKC/KEOPS complex subunit TP53RK; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may t [...] | TP53-target gene 5 protein; May play a significant role in p53/TP53-mediating signaling pathway. | 0.414 |
TP53TG5 | AEBP1 | ENSP00000361811 | ENSP00000223357 | TP53-target gene 5 protein; May play a significant role in p53/TP53-mediating signaling pathway. | Adipocyte enhancer-binding protein 1; [Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix; Belongs to the peptidase M14 family. | 0.433 |
TP53TG5 | C16orf90 | ENSP00000361811 | ENSP00000401335 | TP53-target gene 5 protein; May play a significant role in p53/TP53-mediating signaling pathway. | Uncharacterized protein C16orf90; Chromosome 16 open reading frame 90. | 0.447 |
TP53TG5 | FNTA | ENSP00000361811 | ENSP00000303423 | TP53-target gene 5 protein; May play a significant role in p53/TP53-mediating signaling pathway. | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic- aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. | 0.420 |
TP53TG5 | MADD | ENSP00000361811 | ENSP00000310933 | TP53-target gene 5 protein; May play a significant role in p53/TP53-mediating signaling pathway. | MAP kinase-activating death domain protein; Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is res [...] | 0.441 |
TP53TG5 | PSME3IP1 | ENSP00000361811 | ENSP00000335808 | TP53-target gene 5 protein; May play a significant role in p53/TP53-mediating signaling pathway. | PSME3-interacting protein; Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus. | 0.538 |
TP53TG5 | SYS1 | ENSP00000361811 | ENSP00000243918 | TP53-target gene 5 protein; May play a significant role in p53/TP53-mediating signaling pathway. | Protein SYS1 homolog; Involved in protein trafficking. May serve as a receptor for ARFRP1; Belongs to the SYS1 family. | 0.510 |
TP53TG5 | TP53I11 | ENSP00000361811 | ENSP00000436152 | TP53-target gene 5 protein; May play a significant role in p53/TP53-mediating signaling pathway. | Tumor protein p53 inducible protein 11. | 0.491 |
TP53TG5 | TP53I13 | ENSP00000361811 | ENSP00000301057 | TP53-target gene 5 protein; May play a significant role in p53/TP53-mediating signaling pathway. | Tumor protein p53-inducible protein 13; May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed. | 0.432 |
TP53TG5 | TP53RK | ENSP00000361811 | ENSP00000361186 | TP53-target gene 5 protein; May play a significant role in p53/TP53-mediating signaling pathway. | EKC/KEOPS complex subunit TP53RK; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may t [...] | 0.414 |