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ZMPSTE24 protein (human) - STRING interaction network
"ZMPSTE24" - Zinc metallopeptidase STE24 homolog (S. cerevisiae) in Homo sapiens
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ZMPSTE24Zinc metallopeptidase STE24 homolog (S. cerevisiae); Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C (475 aa)    
Predicted Functional Partners:
ICMT
Isoprenylcysteine carboxyl methyltransferase; Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues (284 aa)
     
  0.988
FNTB
Farnesyltransferase, CAAX box, beta; Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C- terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X (437 aa)
     
 
  0.955
ENSG00000254673
Uncharacterized protein (207 aa)
     
 
  0.953
RCE1
RCE1 homolog, prenyl protein protease (S. cerevisiae); Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (PubMed-10085068) (329 aa)
     
 
  0.921
MRPS5
Mitochondrial ribosomal protein S5 (430 aa)
       
 
  0.789
GALNT2
UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2); Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region (571 aa)
       
      0.774
CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group); This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (440 aa)
       
      0.774
AMPD1
Adenosine monophosphate deaminase 1; AMP deaminase plays a critical role in energy metabolism (780 aa)
   
   
  0.773
LMNA
Lamin A/C; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also [...] (664 aa)
           
  0.744
POR
P450 (cytochrome) oxidoreductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5 (680 aa)
     
      0.722
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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