STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OSER1Oxidative stress-responsive serine-rich protein 1; Oxidative stress responsive serine rich 1 (292 aa)    
Predicted Functional Partners:
ZFAND2B
Zinc finger AN1-type containing 2B
   
    0.817
ZFAND2A
Zinc finger AN1-type containing 2A
   
  
 0.755
ARHGAP17
Rho GTPase-activating protein 17; Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent [...]
      
 0.636
C1orf174
UPF0688 protein C1orf174; Chromosome 1 open reading frame 174; Belongs to the UPF0688 family
      
 0.530
ROMO1
Reactive oxygen species modulator 1; Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation; Belongs to the MGR2 family
      
 0.520
ZFAND1
Zinc finger AN1-type containing 1
   
    0.511
LRRC66
Leucine-rich repeat-containing protein 66; Leucine rich repeat containing 66
      
 0.511
C2orf73
Uncharacterized protein C2orf73; Chromosome 2 open reading frame 73
      
 0.491
HAGHL
Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds
      
 0.480
RPUSD2
RNA pseudouridylate synthase domain containing 2
      
 0.471
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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