| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATP6V1D | ATP6V1E2 | ENSP00000216442 | ENSP00000304891 | V-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. | V-type proton ATPase subunit E 2; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome (By similarity). | 0.999 |
| ATP6V1D | C9orf16 | ENSP00000216442 | ENSP00000362085 | V-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. | UPF0184 protein C9orf16; Chromosome 9 open reading frame 16. | 0.999 |
| ATP6V1E2 | ATP6V1D | ENSP00000304891 | ENSP00000216442 | V-type proton ATPase subunit E 2; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome (By similarity). | V-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. | 0.999 |
| ATP6V1E2 | C9orf16 | ENSP00000304891 | ENSP00000362085 | V-type proton ATPase subunit E 2; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome (By similarity). | UPF0184 protein C9orf16; Chromosome 9 open reading frame 16. | 0.855 |
| C19orf53 | C9orf16 | ENSP00000465432 | ENSP00000362085 | Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy. | UPF0184 protein C9orf16; Chromosome 9 open reading frame 16. | 0.537 |
| C19orf53 | SERF2 | ENSP00000465432 | ENSP00000387187 | Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy. | Small EDRK-rich factor 2; Positive regulator of amyloid protein aggregation and proteotoxicity. Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates. Belongs to the SERF family. | 0.651 |
| C9orf16 | ATP6V1D | ENSP00000362085 | ENSP00000216442 | UPF0184 protein C9orf16; Chromosome 9 open reading frame 16. | V-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. | 0.999 |
| C9orf16 | ATP6V1E2 | ENSP00000362085 | ENSP00000304891 | UPF0184 protein C9orf16; Chromosome 9 open reading frame 16. | V-type proton ATPase subunit E 2; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome (By similarity). | 0.855 |
| C9orf16 | C19orf53 | ENSP00000362085 | ENSP00000465432 | UPF0184 protein C9orf16; Chromosome 9 open reading frame 16. | Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy. | 0.537 |
| C9orf16 | CEP290 | ENSP00000362085 | ENSP00000448012 | UPF0184 protein C9orf16; Chromosome 9 open reading frame 16. | Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. Required for the correct localization of ciliary and phototransduction proteins in retinal photorecepto [...] | 0.824 |
| C9orf16 | KRT20 | ENSP00000362085 | ENSP00000167588 | UPF0184 protein C9orf16; Chromosome 9 open reading frame 16. | Keratin, type I cytoskeletal 20; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity). | 0.838 |
| C9orf16 | KRT73 | ENSP00000362085 | ENSP00000307014 | UPF0184 protein C9orf16; Chromosome 9 open reading frame 16. | Keratin, type II cytoskeletal 73; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). | 0.756 |
| C9orf16 | OIP5 | ENSP00000362085 | ENSP00000220514 | UPF0184 protein C9orf16; Chromosome 9 open reading frame 16. | Protein Mis18-beta; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis; Belongs to the mis18 family. | 0.555 |
| C9orf16 | RNF20 | ENSP00000362085 | ENSP00000373772 | UPF0184 protein C9orf16; Chromosome 9 open reading frame 16. | E3 ubiquitin-protein ligase BRE1A; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradi [...] | 0.813 |
| C9orf16 | SERF2 | ENSP00000362085 | ENSP00000387187 | UPF0184 protein C9orf16; Chromosome 9 open reading frame 16. | Small EDRK-rich factor 2; Positive regulator of amyloid protein aggregation and proteotoxicity. Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates. Belongs to the SERF family. | 0.514 |
| C9orf16 | THAP8 | ENSP00000362085 | ENSP00000292894 | UPF0184 protein C9orf16; Chromosome 9 open reading frame 16. | THAP domain containing 8. | 0.640 |
| CEP290 | C9orf16 | ENSP00000448012 | ENSP00000362085 | Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. Required for the correct localization of ciliary and phototransduction proteins in retinal photorecepto [...] | UPF0184 protein C9orf16; Chromosome 9 open reading frame 16. | 0.824 |
| KRT20 | C9orf16 | ENSP00000167588 | ENSP00000362085 | Keratin, type I cytoskeletal 20; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity). | UPF0184 protein C9orf16; Chromosome 9 open reading frame 16. | 0.838 |
| KRT73 | C9orf16 | ENSP00000307014 | ENSP00000362085 | Keratin, type II cytoskeletal 73; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). | UPF0184 protein C9orf16; Chromosome 9 open reading frame 16. | 0.756 |
| OIP5 | C9orf16 | ENSP00000220514 | ENSP00000362085 | Protein Mis18-beta; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis; Belongs to the mis18 family. | UPF0184 protein C9orf16; Chromosome 9 open reading frame 16. | 0.555 |
