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POU3F4 protein (human) - STRING interaction network
"POU3F4" - POU class 3 homeobox 4 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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POU3F4POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain (361 aa)    
Predicted Functional Partners:
DYX1C1
Dyslexia susceptibility 1 candidate 1; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Axonemal dynein assembly factor required for ciliary motility (420 aa)
       
 
  0.699
L1CAM
L1 cell adhesion molecule; Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons (1257 aa)
           
  0.622
IGF1
Insulin-like growth factor 1 (somatomedin C); The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMe [...] (195 aa)
           
  0.606
PGK1
Phosphoglycerate kinase 1; In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed-2324090). May play a role in sperm motility (PubMed-26677959) (417 aa)
           
  0.595
RFXAP
Regulatory factor X-associated protein; Part of the RFX complex that binds to the X-box of MHC II promoters (272 aa)
           
  0.594
CCDC6
Coiled-coil domain containing 6 (474 aa)
     
   
  0.530
RFX5
Regulatory factor X, 5 (influences HLA class II expression); Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters (616 aa)
       
 
  0.528
SLC16A2
Solute carrier family 16, member 2 (thyroid hormone transporter); Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr (613 aa)
           
  0.528
RFXANK
Regulatory factor X-associated ankyrin-containing protein; Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator (MHC2TA). May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. Isoform RFX-B-delta5 is not involved in the positive regulation of MHC class II genes (260 aa)
           
  0.526
RFX2
Regulatory factor X, 2 (influences HLA class II expression); Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5’-GTNRCC(0-3N)RGYAAC-3’ present on promoters (PubMed-10330134). Probably activates transcription of the testis- specific histone gene HIST1H1T (By similarity) (723 aa)
       
 
  0.521
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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