| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCDC6 | POU3F4 | ENSP00000263102 | ENSP00000362296 | Coiled-coil domain containing 6 | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | 0.530 |
| DYX1C1 | L1CAM | ENSP00000323275 | ENSP00000359074 | Dyslexia susceptibility 1 candidate 1; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Axonemal dynein assembly factor required for ciliary motility | L1 cell adhesion molecule; Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons | 0.687 |
| DYX1C1 | POU3F4 | ENSP00000323275 | ENSP00000362296 | Dyslexia susceptibility 1 candidate 1; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Axonemal dynein assembly factor required for ciliary motility | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | 0.699 |
| DYX1C1 | SLC16A2 | ENSP00000323275 | ENSP00000276033 | Dyslexia susceptibility 1 candidate 1; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Axonemal dynein assembly factor required for ciliary motility | Solute carrier family 16, member 2 (thyroid hormone transporter); Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr | 0.600 |
| IGF1 | POU3F4 | ENSP00000302665 | ENSP00000362296 | Insulin-like growth factor 1 (somatomedin C); The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMe [...] | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | 0.606 |
| L1CAM | DYX1C1 | ENSP00000359074 | ENSP00000323275 | L1 cell adhesion molecule; Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons | Dyslexia susceptibility 1 candidate 1; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Axonemal dynein assembly factor required for ciliary motility | 0.687 |
| L1CAM | POU3F4 | ENSP00000359074 | ENSP00000362296 | L1 cell adhesion molecule; Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | 0.622 |
| L1CAM | SLC16A2 | ENSP00000359074 | ENSP00000276033 | L1 cell adhesion molecule; Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons | Solute carrier family 16, member 2 (thyroid hormone transporter); Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr | 0.528 |
| PGK1 | POU3F4 | ENSP00000362413 | ENSP00000362296 | Phosphoglycerate kinase 1; In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed-2324090). May play a role in sperm motility (PubMed-26677959) | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | 0.595 |
| POU3F4 | CCDC6 | ENSP00000362296 | ENSP00000263102 | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | Coiled-coil domain containing 6 | 0.530 |
| POU3F4 | DYX1C1 | ENSP00000362296 | ENSP00000323275 | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | Dyslexia susceptibility 1 candidate 1; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Axonemal dynein assembly factor required for ciliary motility | 0.699 |
| POU3F4 | IGF1 | ENSP00000362296 | ENSP00000302665 | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | Insulin-like growth factor 1 (somatomedin C); The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMe [...] | 0.606 |
| POU3F4 | L1CAM | ENSP00000362296 | ENSP00000359074 | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | L1 cell adhesion molecule; Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons | 0.622 |
| POU3F4 | PGK1 | ENSP00000362296 | ENSP00000362413 | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | Phosphoglycerate kinase 1; In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed-2324090). May play a role in sperm motility (PubMed-26677959) | 0.595 |
| POU3F4 | RFX2 | ENSP00000362296 | ENSP00000306335 | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | Regulatory factor X, 2 (influences HLA class II expression); Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5’-GTNRCC(0-3N)RGYAAC-3’ present on promoters (PubMed-10330134). Probably activates transcription of the testis- specific histone gene HIST1H1T (By similarity) | 0.521 |
| POU3F4 | RFX5 | ENSP00000362296 | ENSP00000290524 | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | Regulatory factor X, 5 (influences HLA class II expression); Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters | 0.528 |
| POU3F4 | RFXANK | ENSP00000362296 | ENSP00000305071 | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | Regulatory factor X-associated ankyrin-containing protein; Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator (MHC2TA). May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. Isoform RFX-B-delta5 is not involved in the positive regulation of MHC class II genes | 0.526 |
| POU3F4 | RFXAP | ENSP00000362296 | ENSP00000255476 | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | Regulatory factor X-associated protein; Part of the RFX complex that binds to the X-box of MHC II promoters | 0.594 |
| POU3F4 | SLC16A2 | ENSP00000362296 | ENSP00000276033 | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | Solute carrier family 16, member 2 (thyroid hormone transporter); Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr | 0.528 |
| RFX2 | POU3F4 | ENSP00000306335 | ENSP00000362296 | Regulatory factor X, 2 (influences HLA class II expression); Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5’-GTNRCC(0-3N)RGYAAC-3’ present on promoters (PubMed-10330134). Probably activates transcription of the testis- specific histone gene HIST1H1T (By similarity) | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | 0.521 |
