Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARHGAP40 | C11orf98 | ENSP00000362442 | ENSP00000432523 | Rho GTPase-activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | Uncharacterized protein C11orf98; Chromosome 11 open reading frame 98. | 0.507 |
| ARHGAP40 | CD2AP | ENSP00000362442 | ENSP00000352264 | Rho GTPase-activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glom [...] | 0.407 |
| ARHGAP40 | CDC42 | ENSP00000362442 | ENSP00000497733 | Rho GTPase-activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | 0.626 |
| ARHGAP40 | KIAA1755 | ENSP00000362442 | ENSP00000279024 | Rho GTPase-activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | Uncharacterized protein KIAA1755; KIAA1755. | 0.441 |
| ARHGAP40 | RHOA | ENSP00000362442 | ENSP00000400175 | Rho GTPase-activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.631 |
| ARHGAP40 | SH3KBP1 | ENSP00000362442 | ENSP00000380921 | Rho GTPase-activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | SH3 domain-containing kinase-binding protein 1; Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3- kinase ac [...] | 0.405 |
| ARHGAP40 | SLC32A1 | ENSP00000362442 | ENSP00000217420 | Rho GTPase-activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles. | 0.476 |
| ARHGAP40 | TENM2 | ENSP00000362442 | ENSP00000427874 | Rho GTPase-activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | Ten-2 intracellular domain; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer. [Ten-2 intracellular domain]: Induces gene transcription inhibition. | 0.413 |
| ARHGAP40 | VSTM2L | ENSP00000362442 | ENSP00000362560 | Rho GTPase-activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like. | 0.467 |
| C11orf98 | ARHGAP40 | ENSP00000432523 | ENSP00000362442 | Uncharacterized protein C11orf98; Chromosome 11 open reading frame 98. | Rho GTPase-activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | 0.507 |
| CD2AP | ARHGAP40 | ENSP00000352264 | ENSP00000362442 | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glom [...] | Rho GTPase-activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | 0.407 |
| CD2AP | SH3KBP1 | ENSP00000352264 | ENSP00000380921 | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glom [...] | SH3 domain-containing kinase-binding protein 1; Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3- kinase ac [...] | 0.868 |
| CDC42 | ARHGAP40 | ENSP00000497733 | ENSP00000362442 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | Rho GTPase-activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | 0.626 |
| CDC42 | RHOA | ENSP00000497733 | ENSP00000400175 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.955 |
| CDC42 | SH3KBP1 | ENSP00000497733 | ENSP00000380921 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | SH3 domain-containing kinase-binding protein 1; Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3- kinase ac [...] | 0.670 |
| KIAA1755 | ARHGAP40 | ENSP00000279024 | ENSP00000362442 | Uncharacterized protein KIAA1755; KIAA1755. | Rho GTPase-activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | 0.441 |
| KIAA1755 | VSTM2L | ENSP00000279024 | ENSP00000362560 | Uncharacterized protein KIAA1755; KIAA1755. | V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like. | 0.456 |
| RHOA | ARHGAP40 | ENSP00000400175 | ENSP00000362442 | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | Rho GTPase-activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | 0.631 |
| RHOA | CDC42 | ENSP00000400175 | ENSP00000497733 | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | 0.955 |
| RHOA | SH3KBP1 | ENSP00000400175 | ENSP00000380921 | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | SH3 domain-containing kinase-binding protein 1; Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3- kinase ac [...] | 0.507 |
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