node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARFGEF3 | CCDC167 | ENSP00000251691 | ENSP00000362507 | Brefeldin A-inhibited guanine nucleotide-exchange protein 3; Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells. | Coiled-coil domain containing 167. | 0.507 |
ARFGEF3 | CHMP7 | ENSP00000251691 | ENSP00000380794 | Brefeldin A-inhibited guanine nucleotide-exchange protein 3; Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells. | Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway. | 0.424 |
ARFGEF3 | LRRTM4 | ENSP00000251691 | ENSP00000387228 | Brefeldin A-inhibited guanine nucleotide-exchange protein 3; Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells. | Leucine-rich repeat transmembrane neuronal protein 4; May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity). | 0.479 |
ARFGEF3 | PKIA | ENSP00000251691 | ENSP00000379696 | Brefeldin A-inhibited guanine nucleotide-exchange protein 3; Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells. | cAMP-dependent protein kinase inhibitor alpha; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. | 0.407 |
CCDC106 | CCDC167 | ENSP00000465757 | ENSP00000362507 | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity. | Coiled-coil domain containing 167. | 0.448 |
CCDC106 | CCDC178 | ENSP00000465757 | ENSP00000463254 | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity. | Coiled-coil domain containing 178. | 0.422 |
CCDC167 | ARFGEF3 | ENSP00000362507 | ENSP00000251691 | Coiled-coil domain containing 167. | Brefeldin A-inhibited guanine nucleotide-exchange protein 3; Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells. | 0.507 |
CCDC167 | CCDC106 | ENSP00000362507 | ENSP00000465757 | Coiled-coil domain containing 167. | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity. | 0.448 |
CCDC167 | CCDC178 | ENSP00000362507 | ENSP00000463254 | Coiled-coil domain containing 167. | Coiled-coil domain containing 178. | 0.465 |
CCDC167 | CHMP7 | ENSP00000362507 | ENSP00000380794 | Coiled-coil domain containing 167. | Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway. | 0.493 |
CCDC167 | FN3KRP | ENSP00000362507 | ENSP00000269373 | Coiled-coil domain containing 167. | Ketosamine-3-kinase; Ketosamine-3-kinase involved in protein deglycation by mediating phosphorylation of ribuloselysine and psicoselysine on glycated proteins, to generate ribuloselysine-3 phosphate and psicoselysine-3 phosphate, respectively. Ribuloselysine-3 phosphate and psicoselysine-3 phosphate adducts are unstable and decompose under physiological conditions. Not able to phosphorylate fructoselysine. Belongs to the fructosamine kinase family. | 0.449 |
CCDC167 | LRRTM4 | ENSP00000362507 | ENSP00000387228 | Coiled-coil domain containing 167. | Leucine-rich repeat transmembrane neuronal protein 4; May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity). | 0.488 |
CCDC167 | METTL26 | ENSP00000362507 | ENSP00000440765 | Coiled-coil domain containing 167. | Methyltransferase like 26. | 0.425 |
CCDC167 | PKIA | ENSP00000362507 | ENSP00000379696 | Coiled-coil domain containing 167. | cAMP-dependent protein kinase inhibitor alpha; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. | 0.425 |
CCDC167 | PRKCSH | ENSP00000362507 | ENSP00000466134 | Coiled-coil domain containing 167. | Glucosidase 2 subunit beta; Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). | 0.455 |
CCDC167 | SAC3D1 | ENSP00000362507 | ENSP00000436649 | Coiled-coil domain containing 167. | SAC3 domain-containing protein 1; Involved in centrosome duplication and mitotic progression. | 0.443 |
CCDC178 | CCDC106 | ENSP00000463254 | ENSP00000465757 | Coiled-coil domain containing 178. | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity. | 0.422 |
CCDC178 | CCDC167 | ENSP00000463254 | ENSP00000362507 | Coiled-coil domain containing 178. | Coiled-coil domain containing 167. | 0.465 |
CHMP7 | ARFGEF3 | ENSP00000380794 | ENSP00000251691 | Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway. | Brefeldin A-inhibited guanine nucleotide-exchange protein 3; Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells. | 0.424 |
CHMP7 | CCDC167 | ENSP00000380794 | ENSP00000362507 | Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway. | Coiled-coil domain containing 167. | 0.493 |