| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATXN7L3 | ZBTB34 | ENSP00000397259 | ENSP00000362551 | Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...] | Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor. | 0.419 |
| BACH2 | MAFG | ENSP00000257749 | ENSP00000350369 | Transcription regulator protein BACH2; Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation ; Belongs to the bZI [...] | Transcription factor MafG; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor. Transcription factor, component of erythroid- specific transcription factor NFE2L2. Activates globin [...] | 0.981 |
| BACH2 | ZBTB34 | ENSP00000257749 | ENSP00000362551 | Transcription regulator protein BACH2; Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation ; Belongs to the bZI [...] | Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor. | 0.467 |
| LGALS4 | ZBTB34 | ENSP00000302100 | ENSP00000362551 | Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions. | Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor. | 0.654 |
| MAFG | BACH2 | ENSP00000350369 | ENSP00000257749 | Transcription factor MafG; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor. Transcription factor, component of erythroid- specific transcription factor NFE2L2. Activates globin [...] | Transcription regulator protein BACH2; Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation ; Belongs to the bZI [...] | 0.981 |
| MAFG | ZBTB34 | ENSP00000350369 | ENSP00000362551 | Transcription factor MafG; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor. Transcription factor, component of erythroid- specific transcription factor NFE2L2. Activates globin [...] | Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor. | 0.505 |
| RHBDD2 | ZBTB34 | ENSP00000006777 | ENSP00000362551 | Rhomboid domain containing 2; Belongs to the peptidase S54 family. | Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor. | 0.423 |
| RPP14 | ZBTB34 | ENSP00000412894 | ENSP00000362551 | Ribonuclease P protein subunit p14; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Belongs to the eukaryotic/archaeal RNase P protein component 2 family. | Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor. | 0.480 |
| ZBTB34 | ATXN7L3 | ENSP00000362551 | ENSP00000397259 | Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor. | Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...] | 0.419 |
| ZBTB34 | BACH2 | ENSP00000362551 | ENSP00000257749 | Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor. | Transcription regulator protein BACH2; Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation ; Belongs to the bZI [...] | 0.467 |
| ZBTB34 | LGALS4 | ENSP00000362551 | ENSP00000302100 | Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor. | Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions. | 0.654 |
| ZBTB34 | MAFG | ENSP00000362551 | ENSP00000350369 | Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor. | Transcription factor MafG; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor. Transcription factor, component of erythroid- specific transcription factor NFE2L2. Activates globin [...] | 0.505 |
| ZBTB34 | RHBDD2 | ENSP00000362551 | ENSP00000006777 | Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor. | Rhomboid domain containing 2; Belongs to the peptidase S54 family. | 0.423 |
| ZBTB34 | RPP14 | ENSP00000362551 | ENSP00000412894 | Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor. | Ribonuclease P protein subunit p14; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Belongs to the eukaryotic/archaeal RNase P protein component 2 family. | 0.480 |
STRING v12.5 is now available!
