VSTM2L protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

VSTM2L

V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like. (204 aa)

Predicted Functional Partners:

TRIM11

0.537

PRRT3

0.534

MDGA1

0.532

CTNNBL1

0.522

SOWAHA

0.513

C9orf116

0.497

CPNE8

0.470

NSMF

0.469

RCAN2

0.464

HNRNPL

0.457

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C9orf116	SOWAHA	ENSP00000395281	ENSP00000367965	UPF0691 protein C9orf116; Chromosome 9 open reading frame 116.	Ankyrin repeat domain-containing protein SOWAHA; Sosondowah ankyrin repeat domain family member A; Belongs to the SOWAH family.	0.527
C9orf116	VSTM2L	ENSP00000395281	ENSP00000362560	UPF0691 protein C9orf116; Chromosome 9 open reading frame 116.	V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like.	0.497
CPNE8	VSTM2L	ENSP00000329748	ENSP00000362560	Copine-8; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Belongs to the copine family.	V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like.	0.470
CTNNBL1	HNRNPL	ENSP00000355050	ENSP00000221419	Beta-catenin-like protein 1; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.	Heterogeneous nuclear ribonucleoprotein L; Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.	0.695
CTNNBL1	VSTM2L	ENSP00000355050	ENSP00000362560	Beta-catenin-like protein 1; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.	V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like.	0.522
HNRNPL	CTNNBL1	ENSP00000221419	ENSP00000355050	Heterogeneous nuclear ribonucleoprotein L; Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.	Beta-catenin-like protein 1; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.	0.695
HNRNPL	VSTM2L	ENSP00000221419	ENSP00000362560	Heterogeneous nuclear ribonucleoprotein L; Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.	V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like.	0.457
MDGA1	PRRT3	ENSP00000402584	ENSP00000392511	MAM domain-containing glycosylphosphatidylinositol anchor protein 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2.	Proline rich transmembrane protein 3.	0.406
MDGA1	VSTM2L	ENSP00000402584	ENSP00000362560	MAM domain-containing glycosylphosphatidylinositol anchor protein 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2.	V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like.	0.532
NSMF	VSTM2L	ENSP00000360530	ENSP00000362560	NMDA receptor synaptonuclear signaling and neuronal migration factor; Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells; Belongs to the NSMF family.	V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like.	0.469
PRRT3	MDGA1	ENSP00000392511	ENSP00000402584	Proline rich transmembrane protein 3.	MAM domain-containing glycosylphosphatidylinositol anchor protein 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2.	0.406
PRRT3	VSTM2L	ENSP00000392511	ENSP00000362560	Proline rich transmembrane protein 3.	V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like.	0.534
RCAN2	VSTM2L	ENSP00000360425	ENSP00000362560	Calcipressin-2; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development; Belongs to the RCAN family.	V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like.	0.464
SOWAHA	C9orf116	ENSP00000367965	ENSP00000395281	Ankyrin repeat domain-containing protein SOWAHA; Sosondowah ankyrin repeat domain family member A; Belongs to the SOWAH family.	UPF0691 protein C9orf116; Chromosome 9 open reading frame 116.	0.527
SOWAHA	VSTM2L	ENSP00000367965	ENSP00000362560	Ankyrin repeat domain-containing protein SOWAHA; Sosondowah ankyrin repeat domain family member A; Belongs to the SOWAH family.	V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like.	0.513
TRIM11	VSTM2L	ENSP00000284551	ENSP00000362560	E3 ubiquitin-protein ligase TRIM11; E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation [...]	V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like.	0.537
VSTM2L	C9orf116	ENSP00000362560	ENSP00000395281	V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like.	UPF0691 protein C9orf116; Chromosome 9 open reading frame 116.	0.497
VSTM2L	CPNE8	ENSP00000362560	ENSP00000329748	V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like.	Copine-8; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Belongs to the copine family.	0.470
VSTM2L	CTNNBL1	ENSP00000362560	ENSP00000355050	V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like.	Beta-catenin-like protein 1; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.	0.522
VSTM2L	HNRNPL	ENSP00000362560	ENSP00000221419	V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like.	Heterogeneous nuclear ribonucleoprotein L; Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.	0.457