node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCB7 | CHIC1 | ENSP00000253577 | ENSP00000362601 | ATP-binding cassette sub-family B member 7, mitochondrial; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. | Cysteine-rich hydrophobic domain-containing protein 1; Cysteine rich hydrophobic domain 1; Belongs to the CHIC family. | 0.472 |
ABCB7 | RLIM | ENSP00000253577 | ENSP00000328059 | ATP-binding cassette sub-family B member 7, mitochondrial; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. | E3 ubiquitin-protein ligase RLIM; E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of [...] | 0.510 |
CDX4 | CHIC1 | ENSP00000362613 | ENSP00000362601 | Homeobox protein CDX-4; Caudal type homeobox 4; Belongs to the Caudal homeobox family. | Cysteine-rich hydrophobic domain-containing protein 1; Cysteine rich hydrophobic domain 1; Belongs to the CHIC family. | 0.595 |
CDX4 | DMRTC1 | ENSP00000362613 | ENSP00000471224 | Homeobox protein CDX-4; Caudal type homeobox 4; Belongs to the Caudal homeobox family. | DMRT like family C1. | 0.418 |
CDX4 | RLIM | ENSP00000362613 | ENSP00000328059 | Homeobox protein CDX-4; Caudal type homeobox 4; Belongs to the Caudal homeobox family. | E3 ubiquitin-protein ligase RLIM; E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of [...] | 0.411 |
CDX4 | SLC16A2 | ENSP00000362613 | ENSP00000465734 | Homeobox protein CDX-4; Caudal type homeobox 4; Belongs to the Caudal homeobox family. | Monocarboxylate transporter 8; Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. | 0.509 |
CDX4 | SLC7A3 | ENSP00000362613 | ENSP00000363417 | Homeobox protein CDX-4; Caudal type homeobox 4; Belongs to the Caudal homeobox family. | Cationic amino acid transporter 3; Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. | 0.445 |
CHIC1 | ABCB7 | ENSP00000362601 | ENSP00000253577 | Cysteine-rich hydrophobic domain-containing protein 1; Cysteine rich hydrophobic domain 1; Belongs to the CHIC family. | ATP-binding cassette sub-family B member 7, mitochondrial; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. | 0.472 |
CHIC1 | CDX4 | ENSP00000362601 | ENSP00000362613 | Cysteine-rich hydrophobic domain-containing protein 1; Cysteine rich hydrophobic domain 1; Belongs to the CHIC family. | Homeobox protein CDX-4; Caudal type homeobox 4; Belongs to the Caudal homeobox family. | 0.595 |
CHIC1 | CHID1 | ENSP00000362601 | ENSP00000398722 | Cysteine-rich hydrophobic domain-containing protein 1; Cysteine rich hydrophobic domain 1; Belongs to the CHIC family. | Chitinase domain-containing protein 1; Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro); Belongs to the glycosyl hydrolase 18 family. | 0.426 |
CHIC1 | DLG3 | ENSP00000362601 | ENSP00000363480 | Cysteine-rich hydrophobic domain-containing protein 1; Cysteine rich hydrophobic domain 1; Belongs to the CHIC family. | Disks large homolog 3; Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. | 0.492 |
CHIC1 | DMRTC1 | ENSP00000362601 | ENSP00000471224 | Cysteine-rich hydrophobic domain-containing protein 1; Cysteine rich hydrophobic domain 1; Belongs to the CHIC family. | DMRT like family C1. | 0.540 |
CHIC1 | NEXMIF | ENSP00000362601 | ENSP00000055682 | Cysteine-rich hydrophobic domain-containing protein 1; Cysteine rich hydrophobic domain 1; Belongs to the CHIC family. | Neurite extension and migration factor; Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway. May act by regulating expression of protein-coding genes, such as N-cadherins and integrin beta-1 (ITGB1). | 0.456 |
CHIC1 | RLIM | ENSP00000362601 | ENSP00000328059 | Cysteine-rich hydrophobic domain-containing protein 1; Cysteine rich hydrophobic domain 1; Belongs to the CHIC family. | E3 ubiquitin-protein ligase RLIM; E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of [...] | 0.718 |
CHIC1 | SLC16A2 | ENSP00000362601 | ENSP00000465734 | Cysteine-rich hydrophobic domain-containing protein 1; Cysteine rich hydrophobic domain 1; Belongs to the CHIC family. | Monocarboxylate transporter 8; Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. | 0.575 |
CHIC1 | SLC7A3 | ENSP00000362601 | ENSP00000363417 | Cysteine-rich hydrophobic domain-containing protein 1; Cysteine rich hydrophobic domain 1; Belongs to the CHIC family. | Cationic amino acid transporter 3; Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. | 0.450 |
CHIC1 | ZCCHC13 | ENSP00000362601 | ENSP00000345633 | Cysteine-rich hydrophobic domain-containing protein 1; Cysteine rich hydrophobic domain 1; Belongs to the CHIC family. | Zinc finger CCHC-type containing 13. | 0.518 |
CHID1 | CHIC1 | ENSP00000398722 | ENSP00000362601 | Chitinase domain-containing protein 1; Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro); Belongs to the glycosyl hydrolase 18 family. | Cysteine-rich hydrophobic domain-containing protein 1; Cysteine rich hydrophobic domain 1; Belongs to the CHIC family. | 0.426 |
DLG3 | CHIC1 | ENSP00000363480 | ENSP00000362601 | Disks large homolog 3; Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. | Cysteine-rich hydrophobic domain-containing protein 1; Cysteine rich hydrophobic domain 1; Belongs to the CHIC family. | 0.492 |
DMRTC1 | CDX4 | ENSP00000471224 | ENSP00000362613 | DMRT like family C1. | Homeobox protein CDX-4; Caudal type homeobox 4; Belongs to the Caudal homeobox family. | 0.418 |