node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDX4 | CHIC1 | ENSP00000362613 | ENSP00000362601 | Homeobox protein CDX-4; Caudal type homeobox 4; Belongs to the Caudal homeobox family. | Cysteine-rich hydrophobic domain-containing protein 1; Cysteine rich hydrophobic domain 1; Belongs to the CHIC family. | 0.595 |
CDX4 | FGF4 | ENSP00000362613 | ENSP00000168712 | Homeobox protein CDX-4; Caudal type homeobox 4; Belongs to the Caudal homeobox family. | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. | 0.501 |
CDX4 | FGF8 | ENSP00000362613 | ENSP00000321797 | Homeobox protein CDX-4; Caudal type homeobox 4; Belongs to the Caudal homeobox family. | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells. Belongs to the heparin-binding growth factors family. | 0.456 |
CDX4 | ISL1 | ENSP00000362613 | ENSP00000230658 | Homeobox protein CDX-4; Caudal type homeobox 4; Belongs to the Caudal homeobox family. | Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for [...] | 0.580 |
CDX4 | LMO2 | ENSP00000362613 | ENSP00000257818 | Homeobox protein CDX-4; Caudal type homeobox 4; Belongs to the Caudal homeobox family. | Rhombotin-2; Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. | 0.471 |
CDX4 | NAP1L1 | ENSP00000362613 | ENSP00000477538 | Homeobox protein CDX-4; Caudal type homeobox 4; Belongs to the Caudal homeobox family. | Nucleosome assembly protein 1-like 1; Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). | 0.762 |
CDX4 | NAP1L2 | ENSP00000362613 | ENSP00000362616 | Homeobox protein CDX-4; Caudal type homeobox 4; Belongs to the Caudal homeobox family. | Nucleosome assembly protein 1-like 2; Acidic protein which may be involved in interactions with other proteins or DNA; Belongs to the nucleosome assembly protein (NAP) family. | 0.868 |
CDX4 | SLC16A2 | ENSP00000362613 | ENSP00000465734 | Homeobox protein CDX-4; Caudal type homeobox 4; Belongs to the Caudal homeobox family. | Monocarboxylate transporter 8; Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. | 0.509 |
CDX4 | TBPL2 | ENSP00000362613 | ENSP00000247219 | Homeobox protein CDX-4; Caudal type homeobox 4; Belongs to the Caudal homeobox family. | TATA box-binding protein-like protein 2; Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity); Belongs to the TBP family. | 0.911 |
CDX4 | TBX6 | ENSP00000362613 | ENSP00000378650 | Homeobox protein CDX-4; Caudal type homeobox 4; Belongs to the Caudal homeobox family. | T-box transcription factor TBX6; T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity). | 0.488 |
CHIC1 | CDX4 | ENSP00000362601 | ENSP00000362613 | Cysteine-rich hydrophobic domain-containing protein 1; Cysteine rich hydrophobic domain 1; Belongs to the CHIC family. | Homeobox protein CDX-4; Caudal type homeobox 4; Belongs to the Caudal homeobox family. | 0.595 |
CHIC1 | SLC16A2 | ENSP00000362601 | ENSP00000465734 | Cysteine-rich hydrophobic domain-containing protein 1; Cysteine rich hydrophobic domain 1; Belongs to the CHIC family. | Monocarboxylate transporter 8; Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. | 0.575 |
FGF4 | CDX4 | ENSP00000168712 | ENSP00000362613 | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. | Homeobox protein CDX-4; Caudal type homeobox 4; Belongs to the Caudal homeobox family. | 0.501 |
FGF4 | FGF8 | ENSP00000168712 | ENSP00000321797 | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells. Belongs to the heparin-binding growth factors family. | 0.681 |
FGF4 | ISL1 | ENSP00000168712 | ENSP00000230658 | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. | Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for [...] | 0.447 |
FGF8 | CDX4 | ENSP00000321797 | ENSP00000362613 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells. Belongs to the heparin-binding growth factors family. | Homeobox protein CDX-4; Caudal type homeobox 4; Belongs to the Caudal homeobox family. | 0.456 |
FGF8 | FGF4 | ENSP00000321797 | ENSP00000168712 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells. Belongs to the heparin-binding growth factors family. | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. | 0.681 |
FGF8 | ISL1 | ENSP00000321797 | ENSP00000230658 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells. Belongs to the heparin-binding growth factors family. | Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for [...] | 0.619 |
FGF8 | TBX6 | ENSP00000321797 | ENSP00000378650 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells. Belongs to the heparin-binding growth factors family. | T-box transcription factor TBX6; T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity). | 0.738 |
ISL1 | CDX4 | ENSP00000230658 | ENSP00000362613 | Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for [...] | Homeobox protein CDX-4; Caudal type homeobox 4; Belongs to the Caudal homeobox family. | 0.580 |