node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MTCH1 | PSEN1 | ENSP00000362730 | ENSP00000326366 | Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis. | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] | 0.885 |
MTCH1 | SLC25A10 | ENSP00000362730 | ENSP00000446242 | Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis. | Mitochondrial dicarboxylate carrier; Solute carrier family 25 member 10; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.876 |
MTCH1 | SLC25A10-2 | ENSP00000362730 | ENSP00000461324 | Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis. | Mitochondrial dicarboxylate carrier; Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane. | 0.873 |
MTCH1 | SLC25A11 | ENSP00000362730 | ENSP00000225665 | Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis. | Mitochondrial 2-oxoglutarate/malate carrier protein; Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. Involved in the regulation of apoptosis (By similarity). Acts as a tumor-suppressor gene i [...] | 0.766 |
MTCH1 | SLC25A16 | ENSP00000362730 | ENSP00000476815 | Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis. | Graves disease carrier protein; Required for the accumulation of coenzyme A in the mitochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.781 |
MTCH1 | SLC25A17 | ENSP00000362730 | ENSP00000390722 | Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis. | Peroxisomal membrane protein PMP34; Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'- phosphate and bathophenanthroline in vitro. Belongs to the mitochondrial carrie [...] | 0.897 |
MTCH1 | SLC25A28 | ENSP00000362730 | ENSP00000359526 | Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis. | Mitoferrin-2; Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.773 |
MTCH1 | SLC25A3 | ENSP00000362730 | ENSP00000228318 | Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis. | Phosphate carrier protein, mitochondrial; Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP). | 0.864 |
MTCH1 | SLC25A32 | ENSP00000362730 | ENSP00000297578 | Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis. | Mitochondrial folate transporter/carrier; Transports folate across the inner membranes of mitochondria. Can also transport FAD across the mitochondrial inner membrane. | 0.772 |
MTCH1 | SLC25A33 | ENSP00000362730 | ENSP00000306328 | Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis. | Solute carrier family 25 member 33; Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and m [...] | 0.834 |
PSEN1 | MTCH1 | ENSP00000326366 | ENSP00000362730 | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] | Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis. | 0.885 |
SLC25A10 | MTCH1 | ENSP00000446242 | ENSP00000362730 | Mitochondrial dicarboxylate carrier; Solute carrier family 25 member 10; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis. | 0.876 |
SLC25A10 | SLC25A3 | ENSP00000446242 | ENSP00000228318 | Mitochondrial dicarboxylate carrier; Solute carrier family 25 member 10; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Phosphate carrier protein, mitochondrial; Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP). | 0.587 |
SLC25A10-2 | MTCH1 | ENSP00000461324 | ENSP00000362730 | Mitochondrial dicarboxylate carrier; Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane. | Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis. | 0.873 |
SLC25A10-2 | SLC25A3 | ENSP00000461324 | ENSP00000228318 | Mitochondrial dicarboxylate carrier; Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane. | Phosphate carrier protein, mitochondrial; Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP). | 0.587 |
SLC25A11 | MTCH1 | ENSP00000225665 | ENSP00000362730 | Mitochondrial 2-oxoglutarate/malate carrier protein; Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. Involved in the regulation of apoptosis (By similarity). Acts as a tumor-suppressor gene i [...] | Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis. | 0.766 |
SLC25A11 | SLC25A3 | ENSP00000225665 | ENSP00000228318 | Mitochondrial 2-oxoglutarate/malate carrier protein; Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. Involved in the regulation of apoptosis (By similarity). Acts as a tumor-suppressor gene i [...] | Phosphate carrier protein, mitochondrial; Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP). | 0.576 |
SLC25A16 | MTCH1 | ENSP00000476815 | ENSP00000362730 | Graves disease carrier protein; Required for the accumulation of coenzyme A in the mitochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis. | 0.781 |
SLC25A17 | MTCH1 | ENSP00000390722 | ENSP00000362730 | Peroxisomal membrane protein PMP34; Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'- phosphate and bathophenanthroline in vitro. Belongs to the mitochondrial carrie [...] | Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis. | 0.897 |
SLC25A28 | MTCH1 | ENSP00000359526 | ENSP00000362730 | Mitoferrin-2; Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. | Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis. | 0.773 |