C2orf72 protein (human) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

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co-expression

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gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C2orf72	C4orf47	ENSP00000362743	ENSP00000368127	Uncharacterized protein C2orf72; Chromosome 2 open reading frame 72.	UPF0602 protein C4orf47; Chromosome 4 open reading frame 47; Belongs to the UPF0602 family.	0.470
C2orf72	CLBA1	ENSP00000362743	ENSP00000450114	Uncharacterized protein C2orf72; Chromosome 2 open reading frame 72.	Uncharacterized protein CLBA1; Clathrin binding box of aftiphilin containing 1.	0.497
C2orf72	HNRNPH1	ENSP00000362743	ENSP00000349168	Uncharacterized protein C2orf72; Chromosome 2 open reading frame 72.	Heterogeneous nuclear ribonucleoprotein H, N-terminally processed; This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).	0.457
C2orf72	IGFL3	ENSP00000362743	ENSP00000344860	Uncharacterized protein C2orf72; Chromosome 2 open reading frame 72.	Insulin growth factor-like family member 3; Potential ligand of the IGFLR1 cell membrane receptor.	0.429
C2orf72	MAGEE2	ENSP00000362743	ENSP00000362457	Uncharacterized protein C2orf72; Chromosome 2 open reading frame 72.	Melanoma-associated antigen E2; MAGE family member E2.	0.400
C2orf72	PSMD1	ENSP00000362743	ENSP00000309474	Uncharacterized protein C2orf72; Chromosome 2 open reading frame 72.	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.	0.402
C2orf72	WFDC10B	ENSP00000362743	ENSP00000337466	Uncharacterized protein C2orf72; Chromosome 2 open reading frame 72.	Protein WFDC10B; WAP four-disulfide core domain 10B.	0.442
C2orf72	ZNF229	ENSP00000362743	ENSP00000479884	Uncharacterized protein C2orf72; Chromosome 2 open reading frame 72.	Zinc finger protein 229; May be involved in transcriptional regulation.	0.441
C2orf72	ZRANB1	ENSP00000362743	ENSP00000352676	Uncharacterized protein C2orf72; Chromosome 2 open reading frame 72.	Ubiquitin thioesterase ZRANB1; Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling; Belongs to the peptidase C64 family.	0.457
C4orf47	C2orf72	ENSP00000368127	ENSP00000362743	UPF0602 protein C4orf47; Chromosome 4 open reading frame 47; Belongs to the UPF0602 family.	Uncharacterized protein C2orf72; Chromosome 2 open reading frame 72.	0.470
CLBA1	C2orf72	ENSP00000450114	ENSP00000362743	Uncharacterized protein CLBA1; Clathrin binding box of aftiphilin containing 1.	Uncharacterized protein C2orf72; Chromosome 2 open reading frame 72.	0.497
HNRNPH1	C2orf72	ENSP00000349168	ENSP00000362743	Heterogeneous nuclear ribonucleoprotein H, N-terminally processed; This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).	Uncharacterized protein C2orf72; Chromosome 2 open reading frame 72.	0.457
HNRNPH1	ZRANB1	ENSP00000349168	ENSP00000352676	Heterogeneous nuclear ribonucleoprotein H, N-terminally processed; This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).	Ubiquitin thioesterase ZRANB1; Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling; Belongs to the peptidase C64 family.	0.457
IGFL3	C2orf72	ENSP00000344860	ENSP00000362743	Insulin growth factor-like family member 3; Potential ligand of the IGFLR1 cell membrane receptor.	Uncharacterized protein C2orf72; Chromosome 2 open reading frame 72.	0.429
MAGEE2	C2orf72	ENSP00000362457	ENSP00000362743	Melanoma-associated antigen E2; MAGE family member E2.	Uncharacterized protein C2orf72; Chromosome 2 open reading frame 72.	0.400
PSMD1	C2orf72	ENSP00000309474	ENSP00000362743	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.	Uncharacterized protein C2orf72; Chromosome 2 open reading frame 72.	0.402
PSMD1	ZRANB1	ENSP00000309474	ENSP00000352676	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.	Ubiquitin thioesterase ZRANB1; Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling; Belongs to the peptidase C64 family.	0.486
WFDC10B	C2orf72	ENSP00000337466	ENSP00000362743	Protein WFDC10B; WAP four-disulfide core domain 10B.	Uncharacterized protein C2orf72; Chromosome 2 open reading frame 72.	0.442
ZNF229	C2orf72	ENSP00000479884	ENSP00000362743	Zinc finger protein 229; May be involved in transcriptional regulation.	Uncharacterized protein C2orf72; Chromosome 2 open reading frame 72.	0.441
ZRANB1	C2orf72	ENSP00000352676	ENSP00000362743	Ubiquitin thioesterase ZRANB1; Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling; Belongs to the peptidase C64 family.	Uncharacterized protein C2orf72; Chromosome 2 open reading frame 72.	0.457