node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C6orf89 | PI16 | ENSP00000347322 | ENSP00000497550 | Bombesin receptor-activated protein C6orf89; Exhibits histone deacetylase (HDAC) enhancer properties. May play a role in cell cycle progression and wound repair of bronchial epithelial cells. | Peptidase inhibitor 16; May inhibit cardiomyocyte growth. | 0.472 |
CEP290 | PI16 | ENSP00000448012 | ENSP00000497550 | Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. Required for the correct localization of ciliary and phototransduction proteins in retinal photorecepto [...] | Peptidase inhibitor 16; May inhibit cardiomyocyte growth. | 0.518 |
CEP290 | SERPINI2 | ENSP00000448012 | ENSP00000481699 | Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. Required for the correct localization of ciliary and phototransduction proteins in retinal photorecepto [...] | Serpin family I member 2. | 0.435 |
CLEC3B | PI16 | ENSP00000296130 | ENSP00000497550 | Tetranectin; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis. | Peptidase inhibitor 16; May inhibit cardiomyocyte growth. | 0.494 |
EZH2 | KLK3 | ENSP00000320147 | ENSP00000314151 | Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is m [...] | Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. | 0.574 |
EZH2 | PI16 | ENSP00000320147 | ENSP00000497550 | Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is m [...] | Peptidase inhibitor 16; May inhibit cardiomyocyte growth. | 0.504 |
GART | PI16 | ENSP00000371253 | ENSP00000497550 | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family. | Peptidase inhibitor 16; May inhibit cardiomyocyte growth. | 0.831 |
KLK3 | EZH2 | ENSP00000314151 | ENSP00000320147 | Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. | Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is m [...] | 0.574 |
KLK3 | MSMB | ENSP00000314151 | ENSP00000463092 | Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. | Beta-microseminoprotein; Microseminoprotein beta. | 0.921 |
KLK3 | NCOA4 | ENSP00000314151 | ENSP00000463027 | Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. | Nuclear receptor coactivator 4; Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. | 0.567 |
KLK3 | PI16 | ENSP00000314151 | ENSP00000497550 | Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. | Peptidase inhibitor 16; May inhibit cardiomyocyte growth. | 0.568 |
MFAP5 | PI16 | ENSP00000352455 | ENSP00000497550 | Microfibrillar-associated protein 5; May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (By similarity). Component of the elastin-associated microfibrils. | Peptidase inhibitor 16; May inhibit cardiomyocyte growth. | 0.520 |
MSMB | KLK3 | ENSP00000463092 | ENSP00000314151 | Beta-microseminoprotein; Microseminoprotein beta. | Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. | 0.921 |
MSMB | NCOA4 | ENSP00000463092 | ENSP00000463027 | Beta-microseminoprotein; Microseminoprotein beta. | Nuclear receptor coactivator 4; Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. | 0.607 |
MSMB | PI16 | ENSP00000463092 | ENSP00000497550 | Beta-microseminoprotein; Microseminoprotein beta. | Peptidase inhibitor 16; May inhibit cardiomyocyte growth. | 0.844 |
NCOA4 | KLK3 | ENSP00000463027 | ENSP00000314151 | Nuclear receptor coactivator 4; Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. | Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. | 0.567 |
NCOA4 | MSMB | ENSP00000463027 | ENSP00000463092 | Nuclear receptor coactivator 4; Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. | Beta-microseminoprotein; Microseminoprotein beta. | 0.607 |
NCOA4 | PI16 | ENSP00000463027 | ENSP00000497550 | Nuclear receptor coactivator 4; Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. | Peptidase inhibitor 16; May inhibit cardiomyocyte growth. | 0.638 |
PI16 | C6orf89 | ENSP00000497550 | ENSP00000347322 | Peptidase inhibitor 16; May inhibit cardiomyocyte growth. | Bombesin receptor-activated protein C6orf89; Exhibits histone deacetylase (HDAC) enhancer properties. May play a role in cell cycle progression and wound repair of bronchial epithelial cells. | 0.472 |
PI16 | CEP290 | ENSP00000497550 | ENSP00000448012 | Peptidase inhibitor 16; May inhibit cardiomyocyte growth. | Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. Required for the correct localization of ciliary and phototransduction proteins in retinal photorecepto [...] | 0.518 |