node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADO | ATMIN | ENSP00000362888 | ENSP00000299575 | 2-aminoethanethiol dioxygenase. | ATM interactor; Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription. | 0.461 |
ADO | C3 | ENSP00000362888 | ENSP00000245907 | 2-aminoethanethiol dioxygenase. | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | 0.424 |
ADO | CDO1 | ENSP00000362888 | ENSP00000250535 | 2-aminoethanethiol dioxygenase. | Cysteine dioxygenase type 1; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. | 0.986 |
ADO | CSAD | ENSP00000362888 | ENSP00000267085 | 2-aminoethanethiol dioxygenase. | Cysteine sulfinic acid decarboxylase; Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3- sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate. | 0.969 |
ADO | FAM76B | ENSP00000362888 | ENSP00000351631 | 2-aminoethanethiol dioxygenase. | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family. | 0.574 |
ADO | GAD1 | ENSP00000362888 | ENSP00000350928 | 2-aminoethanethiol dioxygenase. | Glutamate decarboxylase 1; Catalyzes the production of GABA. | 0.909 |
ADO | GAD2 | ENSP00000362888 | ENSP00000365437 | 2-aminoethanethiol dioxygenase. | Glutamate decarboxylase 2; Catalyzes the production of GABA. | 0.910 |
ADO | GADL1 | ENSP00000362888 | ENSP00000282538 | 2-aminoethanethiol dioxygenase. | Acidic amino acid decarboxylase GADL1; May catalyze the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. Does not exhibit any decarboxylation activity toward glutamate. | 0.948 |
ADO | SLC6A6 | ENSP00000362888 | ENSP00000481625 | 2-aminoethanethiol dioxygenase. | Sodium- and chloride-dependent taurine transporter; Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake. | 0.419 |
ADO | TATDN2 | ENSP00000362888 | ENSP00000287652 | 2-aminoethanethiol dioxygenase. | Putative deoxyribonuclease TATDN2; Putative deoxyribonuclease. | 0.533 |
ATMIN | ADO | ENSP00000299575 | ENSP00000362888 | ATM interactor; Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription. | 2-aminoethanethiol dioxygenase. | 0.461 |
C3 | ADO | ENSP00000245907 | ENSP00000362888 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | 2-aminoethanethiol dioxygenase. | 0.424 |
C3 | CDO1 | ENSP00000245907 | ENSP00000250535 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Cysteine dioxygenase type 1; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. | 0.686 |
CDO1 | ADO | ENSP00000250535 | ENSP00000362888 | Cysteine dioxygenase type 1; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. | 2-aminoethanethiol dioxygenase. | 0.986 |
CDO1 | C3 | ENSP00000250535 | ENSP00000245907 | Cysteine dioxygenase type 1; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | 0.686 |
CDO1 | CSAD | ENSP00000250535 | ENSP00000267085 | Cysteine dioxygenase type 1; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. | Cysteine sulfinic acid decarboxylase; Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3- sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate. | 0.984 |
CDO1 | GAD1 | ENSP00000250535 | ENSP00000350928 | Cysteine dioxygenase type 1; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. | Glutamate decarboxylase 1; Catalyzes the production of GABA. | 0.932 |
CDO1 | GAD2 | ENSP00000250535 | ENSP00000365437 | Cysteine dioxygenase type 1; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. | Glutamate decarboxylase 2; Catalyzes the production of GABA. | 0.931 |
CDO1 | GADL1 | ENSP00000250535 | ENSP00000282538 | Cysteine dioxygenase type 1; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. | Acidic amino acid decarboxylase GADL1; May catalyze the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. Does not exhibit any decarboxylation activity toward glutamate. | 0.976 |
CDO1 | SLC6A6 | ENSP00000250535 | ENSP00000481625 | Cysteine dioxygenase type 1; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. | Sodium- and chloride-dependent taurine transporter; Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake. | 0.581 |