STRINGSTRING
BSPRY protein (human) - STRING interaction network
"BSPRY" - B-box and SPRY domain containing in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BSPRYB-box and SPRY domain containing; May regulate epithelial calcium transport by inhibiting TRPV5 activity (402 aa)    
Predicted Functional Partners:
TRPV5
Transient receptor potential cation channel, subfamily V, member 5; Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity) (729 aa)
           
  0.641
TRPV6
Transient receptor potential cation channel, subfamily V, member 6; Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin- dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. H [...] (725 aa)
           
  0.612
TRIM44
Tripartite motif containing 44; May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17 (344 aa)
           
  0.559
TRIM23
Tripartite motif containing 23; Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in ’Lys-63’-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit (574 aa)
           
  0.487
RNF207
Ring finger protein 207 (634 aa)
           
  0.466
TRIM8
Tripartite motif containing 8; Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1 (551 aa)
           
  0.451
FSD1
Fibronectin type III and SPRY domain containing 1; May be involved in microtubule organization and stabilization (496 aa)
           
  0.432
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (11%) [HD]