node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GPRIN2 | NPY4R | ENSP00000363436 | ENSP00000363431 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth. | Neuropeptide Y receptor Y4. | 0.735 |
GPRIN2 | PPY | ENSP00000363436 | ENSP00000466009 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth. | Pancreatic icosapeptide; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions. | 0.455 |
NPB | NPW | ENSP00000332766 | ENSP00000456974 | Neuropeptide B-23; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. | Neuropeptide W-23; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30. | 0.999 |
NPB | NPY | ENSP00000332766 | ENSP00000384364 | Neuropeptide B-23; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | 0.663 |
NPB | NPY4R | ENSP00000332766 | ENSP00000363431 | Neuropeptide B-23; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. | Neuropeptide Y receptor Y4. | 0.603 |
NPB | PNOC | ENSP00000332766 | ENSP00000301908 | Neuropeptide B-23; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. | Prepronociceptin; [Nociceptin]: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. [Orphanin FQ2]: Has potent analgesic activity. Belongs to the opioid neuropeptide precursor family. | 0.591 |
NPB | POMC | ENSP00000332766 | ENSP00000384092 | Neuropeptide B-23; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. | 0.598 |
NPB | PPY | ENSP00000332766 | ENSP00000466009 | Neuropeptide B-23; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. | Pancreatic icosapeptide; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions. | 0.546 |
NPB | PYY | ENSP00000332766 | ENSP00000353198 | Neuropeptide B-23; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. | Peptide YY(3-36); This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility. | 0.556 |
NPB | SST | ENSP00000332766 | ENSP00000287641 | Neuropeptide B-23; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. | Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin. | 0.605 |
NPB | SSTR2 | ENSP00000332766 | ENSP00000350198 | Neuropeptide B-23; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. | Somatostatin receptor type 2; Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 [...] | 0.567 |
NPW | NPB | ENSP00000456974 | ENSP00000332766 | Neuropeptide W-23; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30. | Neuropeptide B-23; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. | 0.999 |
NPW | NPY | ENSP00000456974 | ENSP00000384364 | Neuropeptide W-23; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30. | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | 0.675 |
NPW | NPY4R | ENSP00000456974 | ENSP00000363431 | Neuropeptide W-23; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30. | Neuropeptide Y receptor Y4. | 0.584 |
NPW | PNOC | ENSP00000456974 | ENSP00000301908 | Neuropeptide W-23; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30. | Prepronociceptin; [Nociceptin]: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. [Orphanin FQ2]: Has potent analgesic activity. Belongs to the opioid neuropeptide precursor family. | 0.547 |
NPW | POMC | ENSP00000456974 | ENSP00000384092 | Neuropeptide W-23; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30. | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. | 0.668 |
NPW | PPY | ENSP00000456974 | ENSP00000466009 | Neuropeptide W-23; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30. | Pancreatic icosapeptide; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions. | 0.540 |
NPW | PYY | ENSP00000456974 | ENSP00000353198 | Neuropeptide W-23; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30. | Peptide YY(3-36); This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility. | 0.613 |
NPW | SST | ENSP00000456974 | ENSP00000287641 | Neuropeptide W-23; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30. | Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin. | 0.614 |
NPW | SSTR2 | ENSP00000456974 | ENSP00000350198 | Neuropeptide W-23; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30. | Somatostatin receptor type 2; Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 [...] | 0.571 |