node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KRTAP5-2 | MACO1 | ENSP00000400041 | ENSP00000363463 | Keratin-associated protein 5-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 5 family. | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | 0.538 |
MACO1 | KRTAP5-2 | ENSP00000363463 | ENSP00000400041 | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | Keratin-associated protein 5-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 5 family. | 0.538 |
MACO1 | RHCE | ENSP00000363463 | ENSP00000294413 | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | Blood group Rh(CE) polypeptide; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. | 0.545 |
MACO1 | RHOA | ENSP00000363463 | ENSP00000400175 | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.563 |
MACO1 | RHOC | ENSP00000363463 | ENSP00000285735 | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. | 0.563 |
MACO1 | RIC3 | ENSP00000363463 | ENSP00000308820 | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | Protein RIC-3; Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4. | 0.484 |
MACO1 | RSRP1 | ENSP00000363463 | ENSP00000243189 | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | Arginine and serine rich protein 1. | 0.661 |
MACO1 | SYF2 | ENSP00000363463 | ENSP00000236273 | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the SYF2 family. | 0.496 |
MACO1 | SYN1 | ENSP00000363463 | ENSP00000295987 | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | Synapsin-1; Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level. | 0.744 |
MACO1 | TMEM50A | ENSP00000363463 | ENSP00000363478 | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | Transmembrane protein 50A; Belongs to the UPF0220 family. | 0.601 |
MACO1 | YPEL4 | ENSP00000363463 | ENSP00000432648 | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | Protein yippee-like 4; Yippee like 4; Belongs to the yippee family. | 0.506 |
RHCE | MACO1 | ENSP00000294413 | ENSP00000363463 | Blood group Rh(CE) polypeptide; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | 0.545 |
RHCE | RSRP1 | ENSP00000294413 | ENSP00000243189 | Blood group Rh(CE) polypeptide; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. | Arginine and serine rich protein 1. | 0.534 |
RHCE | TMEM50A | ENSP00000294413 | ENSP00000363478 | Blood group Rh(CE) polypeptide; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. | Transmembrane protein 50A; Belongs to the UPF0220 family. | 0.948 |
RHOA | MACO1 | ENSP00000400175 | ENSP00000363463 | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | 0.563 |
RHOA | RHOC | ENSP00000400175 | ENSP00000285735 | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. | 0.951 |
RHOC | MACO1 | ENSP00000285735 | ENSP00000363463 | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | 0.563 |
RHOC | RHOA | ENSP00000285735 | ENSP00000400175 | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.951 |
RIC3 | MACO1 | ENSP00000308820 | ENSP00000363463 | Protein RIC-3; Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4. | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | 0.484 |
RSRP1 | MACO1 | ENSP00000243189 | ENSP00000363463 | Arginine and serine rich protein 1. | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | 0.661 |