node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LEPROT | TMEM50A | ENSP00000483521 | ENSP00000363478 | Leptin receptor gene-related protein; Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. | Transmembrane protein 50A; Belongs to the UPF0220 family. | 0.932 |
LEPROTL1 | TMEM50A | ENSP00000428281 | ENSP00000363478 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. Belongs to the OB-RGRP/VPS55 family. | Transmembrane protein 50A; Belongs to the UPF0220 family. | 0.920 |
MACO1 | RHCE | ENSP00000363463 | ENSP00000294413 | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | Blood group Rh(CE) polypeptide; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. | 0.545 |
MACO1 | RSRP1 | ENSP00000363463 | ENSP00000243189 | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | Arginine and serine rich protein 1. | 0.661 |
MACO1 | SYF2 | ENSP00000363463 | ENSP00000236273 | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the SYF2 family. | 0.496 |
MACO1 | TMEM50A | ENSP00000363463 | ENSP00000363478 | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | Transmembrane protein 50A; Belongs to the UPF0220 family. | 0.601 |
NPEPPS | SERTAD3 | ENSP00000320324 | ENSP00000375882 | Puromycin-sensitive aminopeptidase; Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. | SERTA domain-containing protein 3; Strong transcriptional coactivator. | 0.454 |
NPEPPS | TMEM50A | ENSP00000320324 | ENSP00000363478 | Puromycin-sensitive aminopeptidase; Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. | Transmembrane protein 50A; Belongs to the UPF0220 family. | 0.497 |
NPEPPS | YBX3 | ENSP00000320324 | ENSP00000228251 | Puromycin-sensitive aminopeptidase; Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. | Y-box-binding protein 3; Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). | 0.421 |
RHCE | MACO1 | ENSP00000294413 | ENSP00000363463 | Blood group Rh(CE) polypeptide; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | 0.545 |
RHCE | RSRP1 | ENSP00000294413 | ENSP00000243189 | Blood group Rh(CE) polypeptide; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. | Arginine and serine rich protein 1. | 0.534 |
RHCE | TMEM50A | ENSP00000294413 | ENSP00000363478 | Blood group Rh(CE) polypeptide; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. | Transmembrane protein 50A; Belongs to the UPF0220 family. | 0.948 |
RSRP1 | MACO1 | ENSP00000243189 | ENSP00000363463 | Arginine and serine rich protein 1. | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | 0.661 |
RSRP1 | RHCE | ENSP00000243189 | ENSP00000294413 | Arginine and serine rich protein 1. | Blood group Rh(CE) polypeptide; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. | 0.534 |
RSRP1 | SYF2 | ENSP00000243189 | ENSP00000236273 | Arginine and serine rich protein 1. | Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the SYF2 family. | 0.588 |
RSRP1 | TMEM50A | ENSP00000243189 | ENSP00000363478 | Arginine and serine rich protein 1. | Transmembrane protein 50A; Belongs to the UPF0220 family. | 0.680 |
SERTAD3 | NPEPPS | ENSP00000375882 | ENSP00000320324 | SERTA domain-containing protein 3; Strong transcriptional coactivator. | Puromycin-sensitive aminopeptidase; Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. | 0.454 |
SERTAD3 | TMEM50A | ENSP00000375882 | ENSP00000363478 | SERTA domain-containing protein 3; Strong transcriptional coactivator. | Transmembrane protein 50A; Belongs to the UPF0220 family. | 0.580 |
SERTAD3 | YBX3 | ENSP00000375882 | ENSP00000228251 | SERTA domain-containing protein 3; Strong transcriptional coactivator. | Y-box-binding protein 3; Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). | 0.420 |
SYF2 | MACO1 | ENSP00000236273 | ENSP00000363463 | Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the SYF2 family. | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | 0.496 |