| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AQP10 | KRTAP4-8 | ENSP00000318355 | ENSP00000328444 | Aquaporin-10; [Isoform 1]: Water channel that mediates water transport across cell membranes irrespective of the cytosolic pH. The channel is permeable to glycerol, especially when the cytosolic pH is acidified. Contributes to adipocyte water and glycerol permeability, and may thereby contribute to the utilization of glycerol derived from phospholipid degradation. May contribute to water transport in the intestine (Probable). Belongs to the MIP/aquaporin (TC 1.A.8) family. | Keratin-associated protein 4-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 4 family. | 0.731 |
| AQP10 | NCMAP | ENSP00000318355 | ENSP00000363513 | Aquaporin-10; [Isoform 1]: Water channel that mediates water transport across cell membranes irrespective of the cytosolic pH. The channel is permeable to glycerol, especially when the cytosolic pH is acidified. Contributes to adipocyte water and glycerol permeability, and may thereby contribute to the utilization of glycerol derived from phospholipid degradation. May contribute to water transport in the intestine (Probable). Belongs to the MIP/aquaporin (TC 1.A.8) family. | Noncompact myelin-associated protein; Plays a role in myelin formation. | 0.502 |
| CLDN19 | NCMAP | ENSP00000296387 | ENSP00000363513 | Claudin-19; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. | Noncompact myelin-associated protein; Plays a role in myelin formation. | 0.591 |
| CLDN19 | PMP2 | ENSP00000296387 | ENSP00000256103 | Claudin-19; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. | Myelin P2 protein; May play a role in lipid transport protein in Schwann cells. May bind cholesterol. | 0.418 |
| FABP7 | NCMAP | ENSP00000348931 | ENSP00000363513 | Fatty acid-binding protein, brain; B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity). | Noncompact myelin-associated protein; Plays a role in myelin formation. | 0.424 |
| HAO1 | NCMAP | ENSP00000368066 | ENSP00000363513 | Hydroxyacid oxidase 1; Has 2-hydroxyacid oxidase activity. Most active on the 2- carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. | Noncompact myelin-associated protein; Plays a role in myelin formation. | 0.422 |
| KRTAP4-8 | AQP10 | ENSP00000328444 | ENSP00000318355 | Keratin-associated protein 4-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 4 family. | Aquaporin-10; [Isoform 1]: Water channel that mediates water transport across cell membranes irrespective of the cytosolic pH. The channel is permeable to glycerol, especially when the cytosolic pH is acidified. Contributes to adipocyte water and glycerol permeability, and may thereby contribute to the utilization of glycerol derived from phospholipid degradation. May contribute to water transport in the intestine (Probable). Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.731 |
| KRTAP4-8 | NCMAP | ENSP00000328444 | ENSP00000363513 | Keratin-associated protein 4-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 4 family. | Noncompact myelin-associated protein; Plays a role in myelin formation. | 0.421 |
| LIM2 | NCMAP | ENSP00000221973 | ENSP00000363513 | Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. | Noncompact myelin-associated protein; Plays a role in myelin formation. | 0.593 |
| NCMAP | AQP10 | ENSP00000363513 | ENSP00000318355 | Noncompact myelin-associated protein; Plays a role in myelin formation. | Aquaporin-10; [Isoform 1]: Water channel that mediates water transport across cell membranes irrespective of the cytosolic pH. The channel is permeable to glycerol, especially when the cytosolic pH is acidified. Contributes to adipocyte water and glycerol permeability, and may thereby contribute to the utilization of glycerol derived from phospholipid degradation. May contribute to water transport in the intestine (Probable). Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.502 |
| NCMAP | CLDN19 | ENSP00000363513 | ENSP00000296387 | Noncompact myelin-associated protein; Plays a role in myelin formation. | Claudin-19; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. | 0.591 |
| NCMAP | FABP7 | ENSP00000363513 | ENSP00000348931 | Noncompact myelin-associated protein; Plays a role in myelin formation. | Fatty acid-binding protein, brain; B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity). | 0.424 |
| NCMAP | HAO1 | ENSP00000363513 | ENSP00000368066 | Noncompact myelin-associated protein; Plays a role in myelin formation. | Hydroxyacid oxidase 1; Has 2-hydroxyacid oxidase activity. Most active on the 2- carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. | 0.422 |
| NCMAP | KRTAP4-8 | ENSP00000363513 | ENSP00000328444 | Noncompact myelin-associated protein; Plays a role in myelin formation. | Keratin-associated protein 4-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 4 family. | 0.421 |
| NCMAP | LIM2 | ENSP00000363513 | ENSP00000221973 | Noncompact myelin-associated protein; Plays a role in myelin formation. | Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. | 0.593 |
| NCMAP | PMP2 | ENSP00000363513 | ENSP00000256103 | Noncompact myelin-associated protein; Plays a role in myelin formation. | Myelin P2 protein; May play a role in lipid transport protein in Schwann cells. May bind cholesterol. | 0.586 |
| NCMAP | SCN7A | ENSP00000363513 | ENSP00000496114 | Noncompact myelin-associated protein; Plays a role in myelin formation. | Sodium channel protein type 7 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.433 |
| PMP2 | CLDN19 | ENSP00000256103 | ENSP00000296387 | Myelin P2 protein; May play a role in lipid transport protein in Schwann cells. May bind cholesterol. | Claudin-19; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. | 0.418 |
| PMP2 | NCMAP | ENSP00000256103 | ENSP00000363513 | Myelin P2 protein; May play a role in lipid transport protein in Schwann cells. May bind cholesterol. | Noncompact myelin-associated protein; Plays a role in myelin formation. | 0.586 |
| SCN7A | NCMAP | ENSP00000496114 | ENSP00000363513 | Sodium channel protein type 7 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | Noncompact myelin-associated protein; Plays a role in myelin formation. | 0.433 |
