node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANTKMT | OXLD1 | ENSP00000454380 | ENSP00000363873 | Adenine nucleotide translocase lysine N-methyltransferase; Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration. Probably also trimethylates ANT1/SLC25A4. | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1. | 0.566 |
ANTKMT | TMEM242 | ENSP00000454380 | ENSP00000383594 | Adenine nucleotide translocase lysine N-methyltransferase; Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration. Probably also trimethylates ANT1/SLC25A4. | Transmembrane protein 242; Belongs to the TMEM242 family. | 0.457 |
CARS2 | OXLD1 | ENSP00000257347 | ENSP00000363873 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1. | 0.622 |
CARS2 | TRMT61B | ENSP00000257347 | ENSP00000302801 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial; Methyltransferase that catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC). Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function. In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)-methyltransferase by me [...] | 0.627 |
FMC1 | GRPEL2 | ENSP00000297534 | ENSP00000329558 | Protein FMC1 homolog; Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) ; Belongs to the FMC1 family. | GrpE protein homolog 2, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity); Belongs to the GrpE family. | 0.783 |
FMC1 | OXLD1 | ENSP00000297534 | ENSP00000363873 | Protein FMC1 homolog; Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) ; Belongs to the FMC1 family. | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1. | 0.645 |
GRPEL2 | FMC1 | ENSP00000329558 | ENSP00000297534 | GrpE protein homolog 2, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity); Belongs to the GrpE family. | Protein FMC1 homolog; Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) ; Belongs to the FMC1 family. | 0.783 |
GRPEL2 | OXLD1 | ENSP00000329558 | ENSP00000363873 | GrpE protein homolog 2, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity); Belongs to the GrpE family. | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1. | 0.816 |
HIBCH | OXLD1 | ENSP00000352706 | ENSP00000363873 | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA. | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1. | 0.605 |
MYO1G | OXLD1 | ENSP00000258787 | ENSP00000363873 | Minor histocompatibility antigen HA-2; Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-depen [...] | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1. | 0.526 |
OGFOD3 | OXLD1 | ENSP00000330075 | ENSP00000363873 | 2-oxoglutarate and iron dependent oxygenase domain containing 3; Belongs to the OGFOD3 family. | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1. | 0.520 |
OXLD1 | ANTKMT | ENSP00000363873 | ENSP00000454380 | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1. | Adenine nucleotide translocase lysine N-methyltransferase; Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration. Probably also trimethylates ANT1/SLC25A4. | 0.566 |
OXLD1 | CARS2 | ENSP00000363873 | ENSP00000257347 | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1. | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.622 |
OXLD1 | FMC1 | ENSP00000363873 | ENSP00000297534 | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1. | Protein FMC1 homolog; Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) ; Belongs to the FMC1 family. | 0.645 |
OXLD1 | GRPEL2 | ENSP00000363873 | ENSP00000329558 | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1. | GrpE protein homolog 2, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity); Belongs to the GrpE family. | 0.816 |
OXLD1 | HIBCH | ENSP00000363873 | ENSP00000352706 | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1. | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA. | 0.605 |
OXLD1 | MYO1G | ENSP00000363873 | ENSP00000258787 | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1. | Minor histocompatibility antigen HA-2; Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-depen [...] | 0.526 |
OXLD1 | OGFOD3 | ENSP00000363873 | ENSP00000330075 | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1. | 2-oxoglutarate and iron dependent oxygenase domain containing 3; Belongs to the OGFOD3 family. | 0.520 |
OXLD1 | RPP25L | ENSP00000363873 | ENSP00000297613 | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1. | Ribonuclease P protein subunit p25-like protein; May be a component of ribonuclease P or MRP. | 0.524 |
OXLD1 | TMEM242 | ENSP00000363873 | ENSP00000383594 | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1. | Transmembrane protein 242; Belongs to the TMEM242 family. | 0.501 |