STRINGSTRING
ECE1 protein (human) - STRING interaction network
"ECE1" - Endothelin-converting enzyme 1 in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ECE1Endothelin-converting enzyme 1; Converts big endothelin-1 to endothelin-1; Belongs to the peptidase M13 family (770 aa)    
Predicted Functional Partners:
EDN1
Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family (212 aa)
     
  0.993
EDNRB
Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily (532 aa)
           
  0.735
EDN3
Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands (238 aa)
           
  0.732
EDNRA
Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is- ET1 > ET2 >> ET3 (427 aa)
           
  0.731
IDE
Insulin-degrading enzyme; Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia; M16 metallopeptidases (1019 aa)
           
  0.674
EDN2
Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands (178 aa)
           
  0.669
SPINT1
Kunitz-type protease inhibitor 1; Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14) (529 aa)
           
  0.626
LIAS
Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (372 aa)
           
  0.626
TSR1
Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus (804 aa)
           
  0.625
NAGLU
Alpha-N-acetylglucosaminidase; Involved in the degradation of heparan sulfate (743 aa)
     
   
  0.623
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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