node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C18orf54 | CCDC150 | ENSP00000477654 | ENSP00000373827 | Chromosome 18 open reading frame 54. | Coiled-coil domain containing 150. | 0.596 |
C18orf54 | DEPDC1B | ENSP00000477654 | ENSP00000265036 | Chromosome 18 open reading frame 54. | DEP domain containing 1B. | 0.445 |
C18orf54 | ZNF367 | ENSP00000477654 | ENSP00000364405 | Chromosome 18 open reading frame 54. | Zinc finger protein 367; Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes. | 0.539 |
CCDC150 | C18orf54 | ENSP00000373827 | ENSP00000477654 | Coiled-coil domain containing 150. | Chromosome 18 open reading frame 54. | 0.596 |
CCDC150 | DEPDC1B | ENSP00000373827 | ENSP00000265036 | Coiled-coil domain containing 150. | DEP domain containing 1B. | 0.548 |
CCDC150 | ZNF367 | ENSP00000373827 | ENSP00000364405 | Coiled-coil domain containing 150. | Zinc finger protein 367; Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes. | 0.512 |
DEPDC1B | C18orf54 | ENSP00000265036 | ENSP00000477654 | DEP domain containing 1B. | Chromosome 18 open reading frame 54. | 0.445 |
DEPDC1B | CCDC150 | ENSP00000265036 | ENSP00000373827 | DEP domain containing 1B. | Coiled-coil domain containing 150. | 0.548 |
DEPDC1B | UHRF1 | ENSP00000265036 | ENSP00000479617 | DEP domain containing 1B. | E3 ubiquitin-protein ligase UHRF1; Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylate [...] | 0.558 |
DEPDC1B | ZNF367 | ENSP00000265036 | ENSP00000364405 | DEP domain containing 1B. | Zinc finger protein 367; Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes. | 0.605 |
HABP4 | ZNF367 | ENSP00000364398 | ENSP00000364405 | Intracellular hyaluronan-binding protein 4; RNA-binding protein that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation. Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). Plays a role in pre-mRNA splicing regulation. Binds (via C-terminus) to poly(U) RNA. Involved in mRNA translation regulation, probably at the initiation step. Seems to play a role in PML-nuclear bodies formation. | Zinc finger protein 367; Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes. | 0.511 |
PRXL2C | UBOX5 | ENSP00000364382 | ENSP00000217173 | Peroxiredoxin-like 2C; May regulate positively ERK1/2 signaling and AKT1 activation leading to HIF1A up-regulation with an increased expression of glycolysis genes and enhanced glycolysis. Belongs to the peroxiredoxin-like PRXL2 family. PRXL2C subfamily. | RING finger protein 37; May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. | 0.432 |
PRXL2C | ZNF367 | ENSP00000364382 | ENSP00000364405 | Peroxiredoxin-like 2C; May regulate positively ERK1/2 signaling and AKT1 activation leading to HIF1A up-regulation with an increased expression of glycolysis genes and enhanced glycolysis. Belongs to the peroxiredoxin-like PRXL2 family. PRXL2C subfamily. | Zinc finger protein 367; Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes. | 0.576 |
SMYD1 | UBOX5 | ENSP00000393453 | ENSP00000217173 | Histone-lysine N-methyltransferase SMYD1; Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis; Belongs to the class V-like SAM-binding methyltransferase superfamily. | RING finger protein 37; May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. | 0.504 |
SMYD1 | ZNF367 | ENSP00000393453 | ENSP00000364405 | Histone-lysine N-methyltransferase SMYD1; Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis; Belongs to the class V-like SAM-binding methyltransferase superfamily. | Zinc finger protein 367; Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes. | 0.492 |
TCF19 | UHRF1 | ENSP00000365433 | ENSP00000479617 | Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression. | E3 ubiquitin-protein ligase UHRF1; Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylate [...] | 0.553 |
TCF19 | WDR76 | ENSP00000365433 | ENSP00000263795 | Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression. | WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC; Belongs to the WD repeat DDB2/WDR76 family. | 0.421 |
TCF19 | ZNF367 | ENSP00000365433 | ENSP00000364405 | Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression. | Zinc finger protein 367; Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes. | 0.486 |
UBOX5 | PRXL2C | ENSP00000217173 | ENSP00000364382 | RING finger protein 37; May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. | Peroxiredoxin-like 2C; May regulate positively ERK1/2 signaling and AKT1 activation leading to HIF1A up-regulation with an increased expression of glycolysis genes and enhanced glycolysis. Belongs to the peroxiredoxin-like PRXL2 family. PRXL2C subfamily. | 0.432 |
UBOX5 | SMYD1 | ENSP00000217173 | ENSP00000393453 | RING finger protein 37; May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. | Histone-lysine N-methyltransferase SMYD1; Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis; Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.504 |