| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARSG | LYZL2 | ENSP00000407193 | ENSP00000364467 | Arylsulfatase G; Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. | Lysozyme-like protein 2; Lysozyme like 2. | 0.527 |
| C20orf173 | LYZL2 | ENSP00000403566 | ENSP00000364467 | Uncharacterized protein C20orf173; Chromosome 20 open reading frame 173. | Lysozyme-like protein 2; Lysozyme like 2. | 0.426 |
| DNAJB9 | LYZL2 | ENSP00000249356 | ENSP00000364467 | DnaJ homolog subfamily B member 9; Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also invol [...] | Lysozyme-like protein 2; Lysozyme like 2. | 0.409 |
| ENTPD5 | LYZL2 | ENSP00000335246 | ENSP00000364467 | Ectonucleoside triphosphate diphosphohydrolase 5; Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thia [...] | Lysozyme-like protein 2; Lysozyme like 2. | 0.560 |
| HECTD3 | LYZL2 | ENSP00000361245 | ENSP00000364467 | E3 ubiquitin-protein ligase HECTD3; E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity). | Lysozyme-like protein 2; Lysozyme like 2. | 0.416 |
| LRP11 | LYZL2 | ENSP00000239367 | ENSP00000364467 | Low-density lipoprotein receptor-related protein 11; LDL receptor related protein 11; Belongs to the LDLR family. | Lysozyme-like protein 2; Lysozyme like 2. | 0.419 |
| LYZL1 | LYZL2 | ENSP00000364650 | ENSP00000364467 | Lysozyme-like protein 1; Lysozyme like 1; Belongs to the glycosyl hydrolase 22 family. | Lysozyme-like protein 2; Lysozyme like 2. | 0.941 |
| LYZL2 | ARSG | ENSP00000364467 | ENSP00000407193 | Lysozyme-like protein 2; Lysozyme like 2. | Arylsulfatase G; Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. | 0.527 |
| LYZL2 | C20orf173 | ENSP00000364467 | ENSP00000403566 | Lysozyme-like protein 2; Lysozyme like 2. | Uncharacterized protein C20orf173; Chromosome 20 open reading frame 173. | 0.426 |
| LYZL2 | DNAJB9 | ENSP00000364467 | ENSP00000249356 | Lysozyme-like protein 2; Lysozyme like 2. | DnaJ homolog subfamily B member 9; Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also invol [...] | 0.409 |
| LYZL2 | ENTPD5 | ENSP00000364467 | ENSP00000335246 | Lysozyme-like protein 2; Lysozyme like 2. | Ectonucleoside triphosphate diphosphohydrolase 5; Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thia [...] | 0.560 |
| LYZL2 | HECTD3 | ENSP00000364467 | ENSP00000361245 | Lysozyme-like protein 2; Lysozyme like 2. | E3 ubiquitin-protein ligase HECTD3; E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity). | 0.416 |
| LYZL2 | LRP11 | ENSP00000364467 | ENSP00000239367 | Lysozyme-like protein 2; Lysozyme like 2. | Low-density lipoprotein receptor-related protein 11; LDL receptor related protein 11; Belongs to the LDLR family. | 0.419 |
| LYZL2 | LYZL1 | ENSP00000364467 | ENSP00000364650 | Lysozyme-like protein 2; Lysozyme like 2. | Lysozyme-like protein 1; Lysozyme like 1; Belongs to the glycosyl hydrolase 22 family. | 0.941 |
| LYZL2 | NPTX1 | ENSP00000364467 | ENSP00000307549 | Lysozyme-like protein 2; Lysozyme like 2. | Neuronal pentraxin-1; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. | 0.405 |
| LYZL2 | RSPRY1 | ENSP00000364467 | ENSP00000443176 | Lysozyme-like protein 2; Lysozyme like 2. | Ring finger and SPRY domain containing 1. | 0.401 |
| NPTX1 | LYZL2 | ENSP00000307549 | ENSP00000364467 | Neuronal pentraxin-1; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. | Lysozyme-like protein 2; Lysozyme like 2. | 0.405 |
| RSPRY1 | LYZL2 | ENSP00000443176 | ENSP00000364467 | Ring finger and SPRY domain containing 1. | Lysozyme-like protein 2; Lysozyme like 2. | 0.401 |
