MFSD14B protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	MFSD14B	ENSP00000220592	ENSP00000364493	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Hippocampus abundant transcript-like protein 1; Major facilitator superfamily domain containing 14B.	0.472
AGO2	MFSD3	ENSP00000220592	ENSP00000301327	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Major facilitator superfamily domain containing 3.	0.486
AGO2	MFSD5	ENSP00000220592	ENSP00000442688	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Molybdate-anion transporter; Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum; Belongs to the major facilitator superfamily.	0.457
AGO2	SLC37A3	ENSP00000220592	ENSP00000321498	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Sugar phosphate exchanger 3; Solute carrier family 37 member 3.	0.504
MFSD12	MFSD14B	ENSP00000347583	ENSP00000364493	Major facilitator superfamily domain containing 12.	Hippocampus abundant transcript-like protein 1; Major facilitator superfamily domain containing 14B.	0.485
MFSD12	MFSD5	ENSP00000347583	ENSP00000442688	Major facilitator superfamily domain containing 12.	Molybdate-anion transporter; Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum; Belongs to the major facilitator superfamily.	0.444
MFSD12	MFSD6	ENSP00000347583	ENSP00000376141	Major facilitator superfamily domain containing 12.	Major facilitator superfamily domain containing 6; Belongs to the major facilitator superfamily. MFSD6 family.	0.571
MFSD12	MFSD6L	ENSP00000347583	ENSP00000330051	Major facilitator superfamily domain containing 12.	Major facilitator superfamily domain containing 6 like.	0.592
MFSD14B	AGO2	ENSP00000364493	ENSP00000220592	Hippocampus abundant transcript-like protein 1; Major facilitator superfamily domain containing 14B.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.472
MFSD14B	MFSD12	ENSP00000364493	ENSP00000347583	Hippocampus abundant transcript-like protein 1; Major facilitator superfamily domain containing 14B.	Major facilitator superfamily domain containing 12.	0.485
MFSD14B	MFSD3	ENSP00000364493	ENSP00000301327	Hippocampus abundant transcript-like protein 1; Major facilitator superfamily domain containing 14B.	Major facilitator superfamily domain containing 3.	0.505
MFSD14B	MFSD5	ENSP00000364493	ENSP00000442688	Hippocampus abundant transcript-like protein 1; Major facilitator superfamily domain containing 14B.	Molybdate-anion transporter; Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum; Belongs to the major facilitator superfamily.	0.544
MFSD14B	MFSD6	ENSP00000364493	ENSP00000376141	Hippocampus abundant transcript-like protein 1; Major facilitator superfamily domain containing 14B.	Major facilitator superfamily domain containing 6; Belongs to the major facilitator superfamily. MFSD6 family.	0.529
MFSD14B	MFSD6L	ENSP00000364493	ENSP00000330051	Hippocampus abundant transcript-like protein 1; Major facilitator superfamily domain containing 14B.	Major facilitator superfamily domain containing 6 like.	0.486
MFSD14B	SLC22A18	ENSP00000364493	ENSP00000369948	Hippocampus abundant transcript-like protein 1; Major facilitator superfamily domain containing 14B.	Solute carrier family 22 member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	0.466
MFSD14B	SLC35A3	ENSP00000364493	ENSP00000359172	Hippocampus abundant transcript-like protein 1; Major facilitator superfamily domain containing 14B.	UDP-N-acetylglucosamine transporter; Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate branching of diantennary oligosaccharides; Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.	0.631
MFSD14B	SLC37A3	ENSP00000364493	ENSP00000321498	Hippocampus abundant transcript-like protein 1; Major facilitator superfamily domain containing 14B.	Sugar phosphate exchanger 3; Solute carrier family 37 member 3.	0.502
MFSD14B	UNK	ENSP00000364493	ENSP00000464893	Hippocampus abundant transcript-like protein 1; Major facilitator superfamily domain containing 14B.	RING finger protein unkempt homolog; Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes. Belongs to the unkempt family.	0.475
MFSD3	AGO2	ENSP00000301327	ENSP00000220592	Major facilitator superfamily domain containing 3.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.486
MFSD3	MFSD14B	ENSP00000301327	ENSP00000364493	Major facilitator superfamily domain containing 3.	Hippocampus abundant transcript-like protein 1; Major facilitator superfamily domain containing 14B.	0.505