TMEM255B protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C13orf46	GRTP1	ENSP00000490032	ENSP00000364579	Uncharacterized protein C13orf46; Chromosome 13 open reading frame 46.	Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s).	0.429
C13orf46	TMEM255B	ENSP00000490032	ENSP00000364502	Uncharacterized protein C13orf46; Chromosome 13 open reading frame 46.	Transmembrane protein 255B.	0.495
DGAT2L6	TMEM255B	ENSP00000328036	ENSP00000364502	Diacylglycerol O-acyltransferase 2-like protein 6; Diglyceride acyltransferase that uses fatty acyl-CoA as substrate. Particularly active with oleate as a substrate. Has no wax synthase activity to produce wax esters ; Belongs to the diacylglycerol acyltransferase family.	Transmembrane protein 255B.	0.481
GRTP1	C13orf46	ENSP00000364579	ENSP00000490032	Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s).	Uncharacterized protein C13orf46; Chromosome 13 open reading frame 46.	0.429
GRTP1	HNRNPL	ENSP00000364579	ENSP00000221419	Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s).	Heterogeneous nuclear ribonucleoprotein L; Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.	0.457
GRTP1	TMEM255B	ENSP00000364579	ENSP00000364502	Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s).	Transmembrane protein 255B.	0.403
HNRNPL	GRTP1	ENSP00000221419	ENSP00000364579	Heterogeneous nuclear ribonucleoprotein L; Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.	Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s).	0.457
HNRNPL	TMEM255B	ENSP00000221419	ENSP00000364502	Heterogeneous nuclear ribonucleoprotein L; Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.	Transmembrane protein 255B.	0.457
HNRNPL	WWP1	ENSP00000221419	ENSP00000427793	Heterogeneous nuclear ribonucleoprotein L; Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.	NEDD4-like E3 ubiquitin-protein ligase WWP1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to [...]	0.467
PHYHIP	TMEM255B	ENSP00000320017	ENSP00000364502	Phytanoyl-CoA hydroxylase-interacting protein; Its interaction with PHYH suggests a role in the development of the central system.	Transmembrane protein 255B.	0.602
PWWP3B	TMEM255B	ENSP00000338641	ENSP00000364502	PWWP domain-containing DNA repair factor 3B; PWWP domain containing 3B; Belongs to the PWWP3A family.	Transmembrane protein 255B.	0.438
RHOU	TMEM255B	ENSP00000355652	ENSP00000364502	Rho-related GTP-binding protein RhoU; Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Belongs to the small GTPase superfamily. Rho family.	Transmembrane protein 255B.	0.514
TMEM225B	TMEM255B	ENSP00000492416	ENSP00000364502	Transmembrane protein 225B.	Transmembrane protein 255B.	0.404
TMEM255B	C13orf46	ENSP00000364502	ENSP00000490032	Transmembrane protein 255B.	Uncharacterized protein C13orf46; Chromosome 13 open reading frame 46.	0.495
TMEM255B	DGAT2L6	ENSP00000364502	ENSP00000328036	Transmembrane protein 255B.	Diacylglycerol O-acyltransferase 2-like protein 6; Diglyceride acyltransferase that uses fatty acyl-CoA as substrate. Particularly active with oleate as a substrate. Has no wax synthase activity to produce wax esters ; Belongs to the diacylglycerol acyltransferase family.	0.481
TMEM255B	GRTP1	ENSP00000364502	ENSP00000364579	Transmembrane protein 255B.	Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s).	0.403
TMEM255B	HNRNPL	ENSP00000364502	ENSP00000221419	Transmembrane protein 255B.	Heterogeneous nuclear ribonucleoprotein L; Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.	0.457
TMEM255B	PHYHIP	ENSP00000364502	ENSP00000320017	Transmembrane protein 255B.	Phytanoyl-CoA hydroxylase-interacting protein; Its interaction with PHYH suggests a role in the development of the central system.	0.602
TMEM255B	PWWP3B	ENSP00000364502	ENSP00000338641	Transmembrane protein 255B.	PWWP domain-containing DNA repair factor 3B; PWWP domain containing 3B; Belongs to the PWWP3A family.	0.438
TMEM255B	RHOU	ENSP00000364502	ENSP00000355652	Transmembrane protein 255B.	Rho-related GTP-binding protein RhoU; Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Belongs to the small GTPase superfamily. Rho family.	0.514