STRINGSTRING
TSPYL2 protein (human) - STRING interaction network
"TSPYL2" - TSPY-like 2 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TSPYL2TSPY-like 2; Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression (693 aa)    
Predicted Functional Partners:
KDM5C
Lysine (K)-specific demethylase 5C; Histone demethylase that specifically demethylates ’Lys- 4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-9’, H3 ’Lys-27’, H3 ’Lys-36’, H3 ’Lys-79’ or H4 ’Lys-20’. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-4’. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 [...] (1560 aa)
     
 
  0.825
ZNF687
Zinc finger protein 687; May be involved in transcriptional regulation (1237 aa)
     
 
  0.781
FOXN4
Forkhead box N4; Transcription factor essential for neural and some non- neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5’-ACGC-3’. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4- NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitor [...] (517 aa)
     
      0.775
TBR1
T-box, brain, 1; Probable transcriptional regulator involved in developmental processes. Required for normal brain development (682 aa)
     
 
  0.751
NAP1L1
Nucleosome assembly protein 1-like 1; May be involved in modulating chromatin formation and contribute to regulation of cell proliferation (391 aa)
     
 
  0.698
NAP1L2
Nucleosome assembly protein 1-like 2; Acidic protein which may be involved in interactions with other proteins or DNA (460 aa)
     
 
  0.684
NAP1L3
Nucleosome assembly protein 1-like 3 (506 aa)
     
 
  0.684
ZMYND8
Zinc finger, MYND-type containing 8 (1188 aa)
       
      0.674
NAP1L4
Nucleosome assembly protein 1-like 4 (375 aa)
     
 
  0.663
NAP1L6
Nucleosome assembly protein 1-like 6 (107 aa)
     
 
  0.663
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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