node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BGN | DCN | ENSP00000327336 | ENSP00000052754 | Biglycan; May be involved in collagen fiber assembly. | Decorin; May affect the rate of fibrils formation. | 0.989 |
BGN | ELN | ENSP00000327336 | ENSP00000351807 | Biglycan; May be involved in collagen fiber assembly. | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity). | 0.990 |
BGN | FBN1 | ENSP00000327336 | ENSP00000325527 | Biglycan; May be involved in collagen fiber assembly. | Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] | 0.784 |
BGN | FBN2 | ENSP00000327336 | ENSP00000424571 | Biglycan; May be involved in collagen fiber assembly. | Fibrillin-2 C-terminal peptide; [Fibrillin-2]: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2- containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Belongs to the fibrillin family. | 0.532 |
BGN | LOX | ENSP00000327336 | ENSP00000231004 | Biglycan; May be involved in collagen fiber assembly. | Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. | 0.653 |
BGN | LOXL1 | ENSP00000327336 | ENSP00000261921 | Biglycan; May be involved in collagen fiber assembly. | Lysyl oxidase homolog 1; Active on elastin and collagen substrates. | 0.727 |
BGN | MFAP2 | ENSP00000327336 | ENSP00000364685 | Biglycan; May be involved in collagen fiber assembly. | Microfibrillar-associated protein 2; Component of the elastin-associated microfibrils; Belongs to the MFAP family. | 0.886 |
BGN | MFAP5 | ENSP00000327336 | ENSP00000352455 | Biglycan; May be involved in collagen fiber assembly. | Microfibrillar-associated protein 5; May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (By similarity). Component of the elastin-associated microfibrils. | 0.441 |
DCN | BGN | ENSP00000052754 | ENSP00000327336 | Decorin; May affect the rate of fibrils formation. | Biglycan; May be involved in collagen fiber assembly. | 0.989 |
DCN | ELN | ENSP00000052754 | ENSP00000351807 | Decorin; May affect the rate of fibrils formation. | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity). | 0.993 |
DCN | FBN1 | ENSP00000052754 | ENSP00000325527 | Decorin; May affect the rate of fibrils formation. | Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] | 0.912 |
DCN | FBN2 | ENSP00000052754 | ENSP00000424571 | Decorin; May affect the rate of fibrils formation. | Fibrillin-2 C-terminal peptide; [Fibrillin-2]: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2- containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Belongs to the fibrillin family. | 0.603 |
DCN | LOX | ENSP00000052754 | ENSP00000231004 | Decorin; May affect the rate of fibrils formation. | Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. | 0.616 |
DCN | LOXL1 | ENSP00000052754 | ENSP00000261921 | Decorin; May affect the rate of fibrils formation. | Lysyl oxidase homolog 1; Active on elastin and collagen substrates. | 0.472 |
DCN | MFAP2 | ENSP00000052754 | ENSP00000364685 | Decorin; May affect the rate of fibrils formation. | Microfibrillar-associated protein 2; Component of the elastin-associated microfibrils; Belongs to the MFAP family. | 0.954 |
DCN | MFAP5 | ENSP00000052754 | ENSP00000352455 | Decorin; May affect the rate of fibrils formation. | Microfibrillar-associated protein 5; May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (By similarity). Component of the elastin-associated microfibrils. | 0.490 |
ELN | BGN | ENSP00000351807 | ENSP00000327336 | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity). | Biglycan; May be involved in collagen fiber assembly. | 0.990 |
ELN | DCN | ENSP00000351807 | ENSP00000052754 | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity). | Decorin; May affect the rate of fibrils formation. | 0.993 |
ELN | FBN1 | ENSP00000351807 | ENSP00000325527 | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity). | Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] | 0.999 |
ELN | FBN2 | ENSP00000351807 | ENSP00000424571 | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity). | Fibrillin-2 C-terminal peptide; [Fibrillin-2]: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2- containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Belongs to the fibrillin family. | 0.967 |