node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
H3-2 | H3-3A | ENSP00000499501 | ENSP00000355780 | H3.2 histone. | H3.3 histone A. | 0.871 |
H3-2 | H3-3B | ENSP00000499501 | ENSP00000254810 | H3.2 histone. | Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] | 0.882 |
H3-2 | H3-4 | ENSP00000499501 | ENSP00000355657 | H3.2 histone. | Histone H3.1t; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.865 |
H3-2 | H3-5 | ENSP00000499501 | ENSP00000339835 | H3.2 histone. | Histone H3.3C; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes. | 0.871 |
H3-2 | H3C10 | ENSP00000499501 | ENSP00000358160 | H3.2 histone. | H3 clustered histone 10. | 0.932 |
H3-2 | H3C12 | ENSP00000499501 | ENSP00000352252 | H3.2 histone. | Histone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.944 |
H3-2 | H3C13 | ENSP00000499501 | ENSP00000333277 | H3.2 histone. | Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.903 |
H3-2 | H3C14 | ENSP00000499501 | ENSP00000358154 | H3.2 histone. | H3 clustered histone 14. | 0.901 |
H3-2 | SPIN1 | ENSP00000499501 | ENSP00000365019 | H3.2 histone. | Spindlin-1; Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway. Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes. May play a role in cell- cycle regulation during the transition from gamete to embryo. Involved in oocyte [...] | 0.960 |
H3-2 | SPINDOC | ENSP00000499501 | ENSP00000294244 | H3.2 histone. | Spindlin interactor and repressor of chromatin-binding protein; Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability. Represses the expression of a number of SPIN1-regulated genes and the SPIN1-mediated activation of the Wnt signaling pathway. Can also inhibit the histone methyl-binding abilities of SPIN2A, SPIN2B, SPIN3 and SPIN4. | 0.820 |
H3-3A | H3-2 | ENSP00000355780 | ENSP00000499501 | H3.3 histone A. | H3.2 histone. | 0.871 |
H3-3A | H3-3B | ENSP00000355780 | ENSP00000254810 | H3.3 histone A. | Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] | 0.937 |
H3-3A | H3-4 | ENSP00000355780 | ENSP00000355657 | H3.3 histone A. | Histone H3.1t; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.855 |
H3-3A | H3-5 | ENSP00000355780 | ENSP00000339835 | H3.3 histone A. | Histone H3.3C; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes. | 0.801 |
H3-3A | H3C10 | ENSP00000355780 | ENSP00000358160 | H3.3 histone A. | H3 clustered histone 10. | 0.856 |
H3-3A | H3C12 | ENSP00000355780 | ENSP00000352252 | H3.3 histone A. | Histone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.860 |
H3-3A | H3C13 | ENSP00000355780 | ENSP00000333277 | H3.3 histone A. | Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.871 |
H3-3A | H3C14 | ENSP00000355780 | ENSP00000358154 | H3.3 histone A. | H3 clustered histone 14. | 0.872 |
H3-3A | SPIN1 | ENSP00000355780 | ENSP00000365019 | H3.3 histone A. | Spindlin-1; Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway. Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes. May play a role in cell- cycle regulation during the transition from gamete to embryo. Involved in oocyte [...] | 0.900 |
H3-3A | SPINDOC | ENSP00000355780 | ENSP00000294244 | H3.3 histone A. | Spindlin interactor and repressor of chromatin-binding protein; Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability. Represses the expression of a number of SPIN1-regulated genes and the SPIN1-mediated activation of the Wnt signaling pathway. Can also inhibit the histone methyl-binding abilities of SPIN2A, SPIN2B, SPIN3 and SPIN4. | 0.800 |