node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABHD16A | C6orf47 | ENSP00000379282 | ENSP00000365076 | Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase. Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G). | Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47. | 0.488 |
ABHD16A | GPANK1 | ENSP00000379282 | ENSP00000365071 | Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase. Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G). | G-patch domain and ankyrin repeats 1. | 0.659 |
ABHD16A | LY6G5C | ENSP00000379282 | ENSP00000372724 | Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase. Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G). | Lymphocyte antigen 6 complex locus protein G5c; May have a role in hematopoietic cell differentiation. | 0.617 |
ABHD16A | PRRC2A | ENSP00000379282 | ENSP00000365201 | Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase. Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G). | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. | 0.755 |
C6orf47 | ABHD16A | ENSP00000365076 | ENSP00000379282 | Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47. | Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase. Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G). | 0.488 |
C6orf47 | DXO | ENSP00000365076 | ENSP00000364498 | Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47. | Decapping and exoribonuclease protein; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'- pyrophosphohydrolase activity by [...] | 0.490 |
C6orf47 | ENSP00000485630 | ENSP00000365076 | ENSP00000485630 | Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47. | Utp12 domain-containing protein. | 0.507 |
C6orf47 | FGFR3 | ENSP00000365076 | ENSP00000339824 | Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47. | Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Ph [...] | 0.420 |
C6orf47 | GPANK1 | ENSP00000365076 | ENSP00000365071 | Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47. | G-patch domain and ankyrin repeats 1. | 0.669 |
C6orf47 | LSM2 | ENSP00000365076 | ENSP00000364813 | Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47. | U6 snRNA-associated Sm-like protein LSm2; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. | 0.434 |
C6orf47 | LY6G5C | ENSP00000365076 | ENSP00000372724 | Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47. | Lymphocyte antigen 6 complex locus protein G5c; May have a role in hematopoietic cell differentiation. | 0.574 |
C6orf47 | NELFE | ENSP00000365076 | ENSP00000364578 | Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47. | Negative elongation factor E; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA. Belongs to the RRM NELF-E family. | 0.495 |
C6orf47 | PPP1R15A | ENSP00000365076 | ENSP00000200453 | Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47. | Protein phosphatase 1 regulatory subunit 15A; Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. | 0.419 |
C6orf47 | PRRC2A | ENSP00000365076 | ENSP00000365201 | Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47. | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. | 0.453 |
DXO | C6orf47 | ENSP00000364498 | ENSP00000365076 | Decapping and exoribonuclease protein; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'- pyrophosphohydrolase activity by [...] | Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47. | 0.490 |
DXO | NELFE | ENSP00000364498 | ENSP00000364578 | Decapping and exoribonuclease protein; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'- pyrophosphohydrolase activity by [...] | Negative elongation factor E; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA. Belongs to the RRM NELF-E family. | 0.457 |
ENSP00000485630 | C6orf47 | ENSP00000485630 | ENSP00000365076 | Utp12 domain-containing protein. | Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47. | 0.507 |
FGFR3 | C6orf47 | ENSP00000339824 | ENSP00000365076 | Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Ph [...] | Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47. | 0.420 |
GPANK1 | ABHD16A | ENSP00000365071 | ENSP00000379282 | G-patch domain and ankyrin repeats 1. | Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase. Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G). | 0.659 |
GPANK1 | C6orf47 | ENSP00000365071 | ENSP00000365076 | G-patch domain and ankyrin repeats 1. | Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47. | 0.669 |